Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
State Key Laboratory of Transvascular Implantation Devices, Hangzhou, 310009, China.
Curr Nutr Rep. 2024 Dec;13(4):718-728. doi: 10.1007/s13668-024-00563-7. Epub 2024 Jul 30.
Autoimmune diseases manifest as an immune system response directed against endogenous antigens, exerting a significant influence on a substantial portion of the population. Notably, a leading contributor to morbidity and mortality in this context is cardiovascular disease (CVD). Intriguingly, individuals with autoimmune disorders exhibit a heightened prevalence of CVD compared to the general population. The meticulous management of CV risk factors assumes paramount importance, given the current absence of a standardized solution to this perplexity. This review endeavors to address this challenge from a nutritional perspective.
Emerging evidence suggests that inflammation, a common thread in autoimmune diseases, also plays a pivotal role in the pathogenesis of CVD. Nutritional interventions aimed at reducing inflammation have shown promise in mitigating cardiovascular risk. The integration of nutritional strategies into the management plans for patients with autoimmune diseases offers a holistic approach to reducing cardiovascular risk. While conventional pharmacological treatments remain foundational, the addition of targeted dietary interventions can provide a complementary pathway to improve cardiovascular outcomes.
自身免疫性疾病表现为免疫系统针对内源性抗原的反应，对相当一部分人群产生重大影响。值得注意的是，心血管疾病（CVD）是导致发病率和死亡率的主要原因。有趣的是，与普通人群相比，自身免疫性疾病患者的 CVD 患病率更高。鉴于目前尚无针对这一难题的标准化解决方案，精细管理 CV 风险因素至关重要。本综述从营养角度尝试解决这一挑战。
新出现的证据表明，炎症是自身免疫性疾病的一个共同特征，它在 CVD 的发病机制中也起着关键作用。旨在减轻炎症的营养干预措施在降低心血管风险方面显示出了希望。将营养策略纳入自身免疫性疾病患者的管理计划中，提供了一种降低心血管风险的整体方法。虽然传统的药物治疗仍然是基础，但添加针对性的饮食干预可以提供改善心血管结局的补充途径。
