Institute of Clinical Pharmacology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
National Medical Products Administration (NMPA) Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing, China.
Front Immunol. 2022 Jul 27;13:967506. doi: 10.3389/fimmu.2022.967506. eCollection 2022.
Patients with systemic lupus erythematosus (SLE) are at increased risk of cardiovascular disease (CVD) compared to the general population. However, little is known about the effects of tobacco smoking on CVD in patients with SLE.
To systematically review and summarize the available literature regarding the effects of tobacco smoking on developing CVD in patients with SLE.
We retrieved relevant studies from the following databases: PubMed, EMBASE, Web of Science and China National Knowledge Internet (CNKI) database. Two reviewers independently reviewed the eligible studies, assessed their validity, and extracted relevant data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity.
A total of 10 studies, which comprised 6984 participants, were included in the analysis. The overall quality of evidence was rated as moderate to low. The smoking prevalence among CVD patients was 39.28% (271/690), which was higher than 31.36% (1974/6294) among non-CVD patients. Compared with never-smokers, the risk of developing CVD in current smokers was 1.42 (95% CI: 1.21-1.66). No significant publication bias was found in our meta-analysis.
In spite of the several negative results, this study found that current smokers with SLE have an increased risk of developing CVD, although most of the included studies were in low-to-moderate quality.
https://www.crd.york.ac.uk/prospero/, identifier CRD42022338109.
与普通人群相比，系统性红斑狼疮（SLE）患者患心血管疾病（CVD）的风险增加。然而，关于吸烟对 SLE 患者 CVD 的影响知之甚少。
系统回顾和总结有关吸烟对 SLE 患者发生 CVD 的影响的现有文献。
我们从以下数据库中检索相关研究：PubMed、EMBASE、Web of Science 和中国国家知识基础设施（CNKI）数据库。两名评审员独立审查合格研究，评估其有效性并提取相关数据。进行敏感性和亚组分析以区分异质性来源。
共纳入 10 项研究，共 6984 名参与者。证据的总体质量评分为中等到低。CVD 患者的吸烟率为 39.28%（271/690），高于非 CVD 患者的 31.36%（1974/6294）。与从不吸烟者相比，当前吸烟者发生 CVD 的风险为 1.42（95%CI：1.21-1.66）。我们的荟萃分析未发现明显的发表偏倚。
尽管存在一些负面结果，但本研究发现，当前吸烟的 SLE 患者发生 CVD 的风险增加，尽管大多数纳入的研究质量处于低到中等水平。
https://www.crd.york.ac.uk/prospero/，标识符 CRD42022338109。
