Emerson T E, Lurton J M, Collins M S
Circ Shock. 1985;17(3):213-22.
A rapidly expanding role involving the use of immunoglobulin preparations in conditions other than the classical immunodeficiency syndromes is evident in recent years. Treatment with immunoglobulin may be especially important during infection in which specific antibody to pathogens has been consumed, degraded, or not produced and in cases in which antibiotic treatment is ineffective. Recent studies in animals and humans support this concept, although further studies are needed to fully develop it. This study was completed to explore possible beneficial effects of prophylactic treatment of rodents during severe Salmonella typhimurium peritonitis with a newly developed native immunoglobulin G preparation for intravenous use (IGIV pH 4.25). This study demonstrates that IGIV pH 4.25 increases survival time and decreases absolute mortality, prevents hypotension and acidosis, and ameliorates or prevents changes in variables indicative of organ damage during S. typhimurium bacteremia in the rat. Studies in mice indicate that protection is mediated by antibody to cell surface antigen (s) of S. typhimurium.
近年来，免疫球蛋白制剂在除经典免疫缺陷综合征以外的其他病症中的应用作用迅速扩大，这一点很明显。在病原体特异性抗体已被消耗、降解或未产生的感染期间，以及在抗生素治疗无效的情况下，免疫球蛋白治疗可能尤为重要。尽管还需要进一步研究来充分发展这一概念，但最近在动物和人类身上的研究支持了这一观点。本研究旨在探讨用一种新开发的静脉注射用天然免疫球蛋白G制剂（IGIV pH 4.25）对严重鼠伤寒沙门氏菌腹膜炎的啮齿动物进行预防性治疗可能产生的有益效果。这项研究表明，IGIV pH 4.25可延长存活时间并降低绝对死亡率，预防低血压和酸中毒，并改善或预防大鼠鼠伤寒沙门氏菌菌血症期间指示器官损伤的变量变化。在小鼠身上的研究表明，这种保护作用是由针对鼠伤寒沙门氏菌细胞表面抗原的抗体介导的。
