Ophthalmology Department, Gaziantep University Hospital, Gaziantep, Turkey.
Ophthalmology Clinic, Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.
Indian J Ophthalmol. 2024 Aug 1;72(8):1136-1141. doi: 10.4103/IJO.IJO_3298_23. Epub 2024 Jul 29.
To perform tear meniscus particle analysis using anterior segment spectral domain-optical coherence tomography (SD-OCT) and ImageJ software in keratoconus patients.
A total of 76 participants (76 eyes) were included in the study. A comprehensive analysis of tear meniscus parameters, including tear meniscus height (TMH), tear meniscus depth (TMD), tear meniscus turbidity (TMT), and percentage of area occupied by particles (PAOP) within the meniscus, was performed in kerataconus patients and healthy controls.
TMT was significantly higher in the keratoconus group, while PAOP was significantly lower (P < 0.05). However, TMH and TMD did not show significant differences between the two groups (P > 0.05). There was a negative correlation observed between TMT and PAOP. In binary logistic regression analysis, TMT and Schirmer score were found to be the most influential factors in predicting keratoconus (odds ratio [OR] = 0.995, P = 0.039 and OR = 1.143, P = 0.021, respectively).
This study revealed novel findings on analysis of the tear film in keratoconus patients, with higher TMT and lower POAP levels in the keratoconus group compared to the healthy control group.
使用眼前节谱域光学相干断层扫描（SD-OCT）和 ImageJ 软件对圆锥角膜患者的泪膜半月板颗粒进行分析。
本研究共纳入 76 名参与者（76 只眼）。对圆锥角膜患者和健康对照组的泪膜半月板参数进行综合分析，包括泪膜半月板高度（TMH）、泪膜半月板深度（TMD）、泪膜半月板混浊度（TMT）和半月板内颗粒所占面积百分比（PAOP）。
圆锥角膜组的 TMT 显著升高，而 PAOP 显著降低（P < 0.05）。然而，两组间 TMH 和 TMD 无显著差异（P > 0.05）。TMT 与 PAOP 呈负相关。在二元逻辑回归分析中，TMT 和 Schirmer 评分被发现是预测圆锥角膜的最主要影响因素（比值比 [OR] = 0.995，P = 0.039 和 OR = 1.143，P = 0.021）。
本研究揭示了圆锥角膜患者泪膜分析的新发现，与健康对照组相比，圆锥角膜组的 TMT 较高，PAOP 较低。
