Lee Kwan Bok, Koh Kyung Min, Kwon Young A, Song Sang Wroul, Kim Byoung Yeop, Chung Jae Lim
Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2017 Aug;31(4):306-312. doi: 10.3341/kjo.2016.0056. Epub 2017 Jul 13.
To evaluate changes in the tear meniscus area and tear meniscus height over time in patients with dry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillation of 3% diquafosol ophthalmic solution.
Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscus images acquired by anterior segment spectral-domain optical coherence tomography were analyzed using National Institutes of Health's image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscus height were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosol in one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear film break-up time, corneal staining score by Oxford schema, and meibomian expressibility were also evaluated at baseline, and after 1 week and 1 month of a diquafosol daily regimen.
Sixty eyes from 30 subjects (mean age, 29.3 years; 8 men and 22 women) were included. In eyes receiving diquafosol, tear volume was increased at 5 and 10 minutes compared with baseline. It was also higher than saline instilled eyes at 5, 10, and 30 minutes. Changes in tear volume with respect to baseline were not statistically different after the use of diquafosol for 1 month. Ocular surface disease index score, tear film break-up time, and Oxford cornea stain score were significantly improved after 1 week and 1 month of daily diquafosol instillation, but meibomian expressibility did not change.
Topical diquafosol ophthalmic solution effectively increased tear volume for up to 30 minutes, compared to normal saline in patients with dry eye syndrome.
使用3% 地夸磷索滴眼液滴眼后，通过眼前节谱域光学相干断层扫描技术评估干眼综合征患者泪液半月皱襞面积和高度随时间的变化。
纳入30例轻至中度干眼综合征患者的60只眼。使用美国国立卫生研究院的图像分析软件（ImageJ 1.44p）分析通过眼前节谱域光学相干断层扫描获取的泪液半月皱襞图像。在一只眼滴入一滴地夸磷索，另一只眼滴入生理盐水后，于基线、5分钟、10分钟和30分钟测量泪液半月皱襞面积和高度。还在基线以及地夸磷索每日给药方案1周和1个月后，评估眼表疾病指数评分、泪膜破裂时间、牛津模式角膜染色评分和睑板腺可挤压性的变化。
纳入30名受试者的60只眼（平均年龄29.3岁；8名男性和22名女性）。在接受地夸磷索的眼中，与基线相比，5分钟和10分钟时泪液量增加。在5分钟、10分钟和30分钟时，其泪液量也高于滴入生理盐水的眼。使用地夸磷索1个月后，泪液量相对于基线的变化无统计学差异。每日滴入地夸磷索1周和1个月后，眼表疾病指数评分、泪膜破裂时间和牛津角膜染色评分显著改善，但睑板腺可挤压性未改变。
与生理盐水相比，局部使用地夸磷索滴眼液可有效增加干眼综合征患者的泪液量长达30分钟。
