Retina and Vitreous Services, Anant Bajaj Retina Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2024 Aug 1;72(8):1168-1174. doi: 10.4103/IJO.IJO_2722_23. Epub 2024 Jul 29.
To study the inner and outer retinal functions using a full-field electroretinogram (ERG) before and after intravenous chemotherapy (IVC) in children with retinoblastoma (RB).
Of the 11 eyes, seven had RB and four were normal. All children were examined under anesthesia using a handheld ERG machine with a standard protocol - light-adapted single-flash ERG (fERG), photopic single-flash 3.0- and 30-Hz flickers, and photopic negative response (PhNR) amplitudes at 72 ms (P72). The amplitudes and peak times were compared before and after IVC.
Post-chemotherapy tumor regressed in all seven eyes. Of the seven eyes, the fERG peak time (a-wave) was delayed in two eyes (29%), whereas the b-wave was delayed in six eyes (86%). The fERG amplitude height for a- and b-waves decreased in five eyes (71%) and six eyes (86%), respectively. In addition, photopic flicker 30-Hz b-wave peak time delayed in five eyes (71%), whereas the b-wave amplitude height decreased in six eyes (86%). Simultaneously, the P72 amplitude height decreased in six eyes (86%), whereas the P-ratio increased in all seven eyes (100%). In comparison, the ERG responses improved in three of the four contralateral normal eyes. Overall, the cone function improved in two eyes (29%), whereas cone bipolar cell and retinal ganglion cell (RGC) function improved in one eye (14%) each.
Comparison of light-adapted ERG changes before and after IVC showed reduced amplitudes and delayed peak times for both a and b waveforms, as well as reduced PhNR amplitude attributable to bipolar and RGC injury.
研究视网膜母细胞瘤（RB）患儿静脉化疗（IVC）前后全视野视网膜电图（ERG）的内外视网膜功能。
11 只眼中，7 只为 RB，4 只为正常。所有儿童均在全身麻醉下使用手持式 ERG 机，采用标准方案进行检查——明适应单次闪光 ERG（fERG）、明适应 3.0Hz 和 30Hz 闪烁光、72ms 时的光负反应（PhNR）振幅（P72）。比较 IVC 前后的振幅和峰值时间。
化疗后所有 7 只眼的肿瘤均消退。7 只眼中，2 只眼（29%）的 fERG 峰时（a 波）延迟，6 只眼（86%）的 b 波延迟。fERG 的 a-和 b-波振幅高度在 5 只眼（71%）和 6 只眼（86%）中分别降低。此外，5 只眼（71%）的 30Hz 闪烁光 b 波峰时延迟，而 6 只眼（86%）的 b 波振幅高度降低。同时，6 只眼（86%）的 P72 振幅高度降低，而 7 只眼（100%）的 P 比值升高。相比之下，4 只对侧正常眼中有 3 只的 ERG 反应改善。总的来说，2 只眼（29%）的锥细胞功能改善，而 1 只眼（14%）的锥体细胞双极细胞和视网膜神经节细胞（RGC）功能改善。
比较 IVC 前后明适应 ERG 变化，发现 a 和 b 波的振幅降低，峰时延迟，以及双极和 RGC 损伤导致的 PhNR 振幅降低。
