UCIBIO, Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
UCIBIO, Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal.
Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167446. doi: 10.1016/j.bbadis.2024.167446. Epub 2024 Jul 29.
Carbon monoxide (CO) is a ubiquitously produced endogenous gas in mammalian cells and is involved in stress response being considered as a cytoprotective and homeostatic factor. In the present review, the underlying mechanisms of CO are discussed, in particular CO's impact on cellular metabolism affecting cell fate and function. One of the principal signaling molecules of CO is reactive oxygen species (ROS), particularly hydrogen peroxide, which is mainly generated at the mitochondrial level. Likewise, CO acts on mitochondria modulating oxidative phosphorylation and mitochondria quality control, namely mitochondrial biogenesis (mitobiogenesis) and mitophagy. Other metabolic pathways are also involved in CO's mode of action such as glycolysis and pentose phosphate pathway. The review ends with some new perspectives on CO Biology research. Carboxyhemoglobin (COHb) formation can also be implicated in the CO mode of action, as well as its potential biological role. Finally, other organelles such as peroxisomes hold the potential to be targeted and modulated by CO.
一氧化碳（CO）是哺乳动物细胞中普遍产生的内源性气体，参与应激反应，被认为是一种细胞保护和体内平衡的因素。在本综述中，讨论了 CO 的潜在机制，特别是 CO 对影响细胞命运和功能的细胞代谢的影响。CO 的主要信号分子之一是活性氧（ROS），特别是过氧化氢，主要在线粒体水平产生。同样，CO 作用于线粒体，调节氧化磷酸化和线粒体质量控制，即线粒体生物发生（mitobiogenesis）和线粒体自噬。其他代谢途径也参与了 CO 的作用模式，如糖酵解和戊糖磷酸途径。综述最后对 CO 生物学研究的一些新视角进行了探讨。一氧化碳合血红蛋白（COHb）的形成也可能与 CO 的作用模式及其潜在的生物学作用有关。最后，其他细胞器，如过氧化物酶体，也有可能成为 CO 的作用靶点和调节对象。
