Müller Sebastian, Cañeque Tatiana, Solier Stéphanie, Rodriguez Raphaël
Institut Curie, CNRS, INSERM, PSL Research University, Equipe labellisée Ligue Contre Le Cancer, Paris, France.
Institut Curie, CNRS, INSERM, PSL Research University, Equipe labellisée Ligue Contre Le Cancer, Paris, France; Department of Genetics, Institut Curie, Paris, France; Paris Saclay University, UVSQ, Montigny-le-Bretonneux, France.
Trends Cell Biol. 2025 Feb;35(2):105-114. doi: 10.1016/j.tcb.2024.07.005. Epub 2024 Jul 29.
Whereas genetic mutations can alter cell properties, nongenetic mechanisms can drive rapid and reversible adaptations to changes in their physical environment, a phenomenon termed 'cell-state transition'. Metals, in particular copper and iron, have been shown to be rate-limiting catalysts of cell-state transitions controlling key chemical reactions in mitochondria and the cell nucleus, which govern metabolic and epigenetic changes underlying the acquisition of distinct cell phenotypes. Acquisition of a distinct cell identity, independently of genetic alterations, is an underlying phenomenon of various biological processes, including development, inflammation, erythropoiesis, aging, and cancer. Here, mechanisms that have been uncovered related to the role of these metals in the regulation of cell plasticity are described, illustrating how copper and iron can be exploited for therapeutic intervention.
虽然基因突变可以改变细胞特性，但非遗传机制可以驱动细胞对其物理环境变化进行快速且可逆的适应，这一现象被称为“细胞状态转变”。金属，特别是铜和铁，已被证明是细胞状态转变的限速催化剂，控制着线粒体和细胞核中的关键化学反应，这些反应决定了获得不同细胞表型所涉及的代谢和表观遗传变化。独立于基因改变而获得独特的细胞身份是包括发育、炎症、红细胞生成、衰老和癌症在内的各种生物学过程的潜在现象。本文描述了与这些金属在调节细胞可塑性中的作用相关的已发现机制，阐明了如何利用铜和铁进行治疗干预。
