炎症与肿瘤中癌症和免疫代谢的异同
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.
作者信息
Andrejeva Gabriela, Rathmell Jeffrey C
机构信息
Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
出版信息
Cell Metab. 2017 Jul 5;26(1):49-70. doi: 10.1016/j.cmet.2017.06.004.
It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occur in the immune system as cells transition from resting state to stimulated effectors. A key finding in immune metabolism is that the metabolic programs of different cell subsets are distinctly associated with immunological function. Further, interruption of those metabolic pathways can shift immune cell fate to modulate immunity. These studies have identified numerous metabolic similarities between cancer and immune cells but also critical differences that may be exploited and that affect treatment of cancer and immunological diseases.
近100年来，人们已经认识到癌细胞在代谢上与静息组织不同。最近人们还了解到，这种代谢表型并非癌细胞所特有，而是反映了增殖细胞的特征。随着细胞从静息状态转变为活化效应细胞，免疫系统中也会发生类似的代谢转变。免疫代谢的一个关键发现是，不同细胞亚群的代谢程序与免疫功能明显相关。此外，这些代谢途径的中断可以改变免疫细胞的命运以调节免疫。这些研究已经确定了癌症细胞和免疫细胞之间存在许多代谢相似性，但也存在可能被利用且影响癌症和免疫疾病治疗的关键差异。
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