Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK; Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK.
Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, B15 2GW, UK.
Nutr Metab Cardiovasc Dis. 2024 Oct;34(10):2227-2239. doi: 10.1016/j.numecd.2024.06.008. Epub 2024 Jun 20.
Obesity is a leading contributor to global morbidity and mortality. Short sleep duration is significantly associated with the incidence of obesity, however, it remains unclear whether this relationship is influenced by sex. The purpose of this meta-analysis was to systematically evaluate the evidence of whether the association between short sleep duration and obesity differs between males and females.
The protocol was registered with PROSPERO (CRD42023374205). From inception through June 2023, Medline, Embase and Web of Science databases were searched for longitudinal cohort studies with minimum 12 months of observation. The quality of studies was assessed using the Newcastle-Ottawa Quality Assessment for Cohort Studies. Results were pooled using a random effects model. Results are expressed as ratio of odds ratios (ROR) with 95% confidence interval (CI). ROR directly estimates the relative strength of the association of interest (measured as odds ratio [OR] between females and males). Sensitivity analysis was performed and inconsistency between studies was assessed using I statistics. A total of 4582 articles were retrieved with the search strategy, of which 6 were included. The meta-analysis indicated that the association between short sleep duration and obesity incidence was statistically significant in both men [OR 1.26 (95% CI 1.13-1.40)] and women [OR 1.36 (95% CI 1.16-1.59)]. However, it did not differ significantly between sexes ROR (women/men) 1.04 (95%CI 0.79-1.36; I 20.1%).
This meta-analysis indicates that women and men who subjectively report short sleep duration have similarly increased risks of incident obesity.
肥胖是全球发病率和死亡率的主要原因之一。睡眠持续时间短与肥胖的发生显著相关，但尚不清楚这种关系是否受性别影响。本荟萃分析的目的是系统评估短睡眠持续时间与肥胖之间的关联在男性和女性之间是否存在差异的证据。
该方案已在 PROSPERO（CRD42023374205）中注册。从开始到 2023 年 6 月，通过 Medline、Embase 和 Web of Science 数据库搜索了至少 12 个月观察期的纵向队列研究。使用纽卡斯尔-渥太华质量评估量表评估研究质量。使用随机效应模型汇总结果。结果表示为比值比（ROR）和 95%置信区间（CI）。ROR 直接估计感兴趣的关联的相对强度（以女性和男性之间的比值比 [OR] 测量）。进行了敏感性分析，并使用 I 统计评估了研究之间的不一致性。通过搜索策略检索到 4582 篇文章，其中 6 篇被纳入。荟萃分析表明，短睡眠持续时间与肥胖发生率之间的关联在男性[OR 1.26（95%CI 1.13-1.40）]和女性[OR 1.36（95%CI 1.16-1.59）]中均具有统计学意义。然而，性别之间的 ROR（女性/男性）差异不显著[1.04（95%CI 0.79-1.36；I 20.1%）]。
本荟萃分析表明，主观报告睡眠持续时间短的女性和男性肥胖的发生风险相似增加。
