Murata Tsuyoshi, Isogami Hirotaka, Imaizumi Karin, Fukuda Toma, Kyozuka Hyo, Yasuda Shun, Yamaguchi Akiko, Sato Akiko, Ogata Yuka, Shinoki Kosei, Hosoya Mitsuaki, Yasumura Seiji, Hashimoto Koichi, Nishigori Hidekazu, Fujimori Keiya
Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Arch Gynecol Obstet. 2024 Aug;310(2):1089-1098. doi: 10.1007/s00404-023-07203-5. Epub 2023 Oct 13.
To evaluate differences in maternal characteristics and obstetric and offspring childhood outcomes between births at and after 37 weeks of gestation (referred to as term and post-term births) according to the use of tocolytic treatment.
Data for 63,409 women with singleton births at and after 37 weeks of gestation were analyzed using data from the Japan Environment and Children's Study (JECS). We compared maternal characteristics, obstetric outcomes, and offspring childhood outcomes between term and post-term births exposed and not exposed to tocolytic treatment. Additionally, multivariable logistic regression models were used to calculate adjusted odds ratios for offspring childhood outcomes with significant between-group differences in the univariable analysis, with term and post-term births without tocolytic agents as the reference group.
We observed differences in maternal characteristics and obstetric outcomes between term and post-term births exposed and not exposed to tocolytic treatment. The incidence of offspring childhood developmental disorders showed no significant between-group differences. However, participants exposed to tocolytic agents had higher incidence of offspring childhood allergic disorders. The adjusted odds ratio for any of the offspring childhood allergic disorders in term and post-term births with tocolytic agents was 1.08 (95% confidence interval, 1.03-1.13).
This study found no significant difference in the incidence of offspring developmental disorders between term and post-term births exposed and not exposed to tocolytic treatment. However, tocolytic treatment was associated with differences in maternal characteristics and obstetric outcomes, along with a marginal increase in the incidence of childhood allergic disorders in offspring.
根据宫缩抑制剂的使用情况，评估妊娠37周及以后分娩（分别称为足月和过期产）的产妇特征、产科结局及子代儿童期结局的差异。
利用日本环境与儿童研究（JECS）的数据，分析了63409例妊娠37周及以后单胎分娩的妇女的数据。我们比较了接受和未接受宫缩抑制剂治疗的足月和过期产之间的产妇特征、产科结局及子代儿童期结局。此外，多变量逻辑回归模型用于计算单变量分析中组间存在显著差异的子代儿童期结局的调整比值比，以未使用宫缩抑制剂的足月和过期产作为参照组。
我们观察到接受和未接受宫缩抑制剂治疗的足月和过期产之间产妇特征和产科结局存在差异。子代儿童期发育障碍的发生率在组间无显著差异。然而，接受宫缩抑制剂治疗的参与者子代儿童期过敏性疾病的发生率较高。使用宫缩抑制剂的足月和过期产中任何子代儿童期过敏性疾病的调整比值比为1.08（95%置信区间，1.03 - 1.13）。
本研究发现，接受和未接受宫缩抑制剂治疗的足月和过期产之间，子代发育障碍的发生率无显著差异。然而，宫缩抑制剂治疗与产妇特征和产科结局的差异有关，同时子代儿童期过敏性疾病的发生率略有增加。
