Kaverina N V, Skoldinov A P, Senova Z P, Gritsenko A N, Lyskovtsev V V
Farmakol Toksikol. 1985 Sep-Oct;48(5):43-9.
Study of the relationship between the chemical structure and pharmacological action in the series of dialkylaminoacyl derivatives of phenothiazines made it possible to discover etacyzine (a diethylamine analog of etmozine). Comparison of the pharmacological action of etacyzine with that of etmozine demonstrated that the replacement of the morpholine radical of the side chain of the phenothiazine ring by the diethylamine one leads to the potentiation and increase of the duration of the antiarrhythmic effect, emergence of anti-fibrillary activity, antiischemic properties and to the ability to restrict the size of experimental myocardial infarction.
对吩噻嗪系列二烷基氨基酰衍生物的化学结构与药理作用之间关系的研究，使得发现乙卡嗪（乙吗噻嗪的二乙胺类似物）成为可能。将乙卡嗪与乙吗噻嗪的药理作用进行比较表明，用二乙胺基团取代吩噻嗪环侧链的吗啉基团会导致抗心律失常作用增强、持续时间延长，出现抗纤颤活性、抗缺血特性以及限制实验性心肌梗死面积的能力。
