Morlacchi F, Trapani G, Losacco V, Armenise D
Farmaco Sci. 1985 Sep;40(9):671-82.
Synthesis and antimicrobial activity of some N-substituted aza- and diaza-phenylcycloalkanes are reported. All the compounds screened in vitro show significant antibacterial and antimycotic activities. Particularly, compounds of the N-(ethoxymethyl)phenylpiperidine series, show activity towards S. aureus 1,2-1,9 superior to ampicillin. Furthermore the microbiological results indicate that the latter activity depends on the position of the phenyl-substituent.
报道了一些N-取代的氮杂和二氮杂苯基环烷烃的合成及其抗菌活性。所有体外筛选的化合物均显示出显著的抗菌和抗真菌活性。特别是，N-(乙氧基甲基)苯基哌啶系列化合物对金黄色葡萄球菌1,2 - 1,9的活性优于氨苄西林。此外，微生物学结果表明，后者的活性取决于苯基取代基的位置。
