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输血可使习惯性流产女性产生/增加先前不存在/较弱的封闭抗体。

Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.

作者信息

Unander A M, Lindholm A, Olding L B

出版信息

Fertil Steril. 1985 Dec;44(6):766-71. doi: 10.1016/s0015-0282(16)49035-7.

DOI:10.1016/s0015-0282(16)49035-7
PMID:3908145
Abstract

Women who suffered recurrent spontaneous abortions of unknown cause were studied for cellular reactivity and blocking antibody in a one-way mixed lymphocyte culture. A defined group of 20 women whose serum displayed no blocking capacity was given three transfusions of leukocyte-rich erythrocyte concentrates. Serum from all women displayed significant blocking capacity 2 months after the third transfusion. Because blocking antibody seems to be one of the necessary prerequisites for successful pregnancy, leukocyte transfusions from third-party donors ought to be an effective cure for habitual abortion in selected cases.

摘要

对原因不明的复发性自然流产女性进行单向混合淋巴细胞培养中的细胞反应性和封闭抗体研究。选定一组20名血清无封闭能力的女性,给予三次富含白细胞的红细胞浓缩物输血。在第三次输血后2个月,所有女性的血清均显示出显著的封闭能力。由于封闭抗体似乎是成功妊娠的必要先决条件之一,因此来自第三方供体的白细胞输血在特定病例中应该是习惯性流产的一种有效治疗方法。

相似文献

1
Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.输血可使习惯性流产女性产生/增加先前不存在/较弱的封闭抗体。
Fertil Steril. 1985 Dec;44(6):766-71. doi: 10.1016/s0015-0282(16)49035-7.
2
Transfusions of leukocyte-rich erythrocyte concentrates: a successful treatment in selected cases of habitual abortion.富含白细胞的红细胞浓缩液输血:习惯性流产特定病例的一种成功治疗方法。
Am J Obstet Gynecol. 1986 Mar;154(3):516-20. doi: 10.1016/0002-9378(86)90593-4.
3
Opinions on treatment of women with habitual abortion based on investigations for blocking antibody and autoantibodies.
Am J Reprod Immunol. 1991 Aug;26(1):32-7. doi: 10.1111/j.1600-0897.1991.tb00699.x.
4
Dialyzable serum factors after cellular immunity in pregnancy.妊娠期间细胞免疫后的可透析血清因子。
Experientia. 1981 May 15;37(5):515-6. doi: 10.1007/BF01986170.
5
[Comparative study of the third party and paternal leukocyte immunization in recurrent spontaneous abortion of lowered maternal-fetal immuno-recognition].[母胎免疫识别降低所致复发性自然流产中第三方与父方白细胞免疫的比较研究]
Zhonghua Fu Chan Ke Za Zhi. 1998 Oct;33(10):597-600.
6
The results of investigations for blocking antibody and autoantibodies help to choose between different immunological treatments for recurrent abortion.封闭抗体和自身抗体的检测结果有助于在复发性流产的不同免疫治疗方法之间做出选择。
Acta Eur Fertil. 1989 Jul-Aug;20(4):193-8.
7
[Prevention of habitual abortion by buffycoat transfusions].[通过白细胞层输血预防习惯性流产]
Z Geburtshilfe Perinatol. 1985 Sep-Oct;189(5):197-201.
8
Prevention of recurrent spontaneous abortions by leukocyte transfusions.通过白细胞输血预防复发性自然流产。
J R Soc Med. 1985 Aug;78(8):623-7. doi: 10.1177/014107688507800804.
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Interpretation of blocking activity in maternal serum depends on the equation used for calculation of mixed lymphocyte culture results.母血中阻断活性的解读取决于用于计算混合淋巴细胞培养结果的公式。
Clin Exp Immunol. 1990 Nov;82(2):363-8. doi: 10.1111/j.1365-2249.1990.tb05454.x.
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Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion.混合淋巴细胞反应阻断因子的诱导与胎儿丢失的预防:一项针对复发性自然流产女性的父方淋巴细胞免疫的双盲随机试验。
Int Immunopharmacol. 2004 Feb;4(2):289-98. doi: 10.1016/j.intimp.2004.01.001.

引用本文的文献

1
Intravenous immune globulin in recurrent abortion.复发性流产中的静脉注射免疫球蛋白
Clin Exp Immunol. 1994 Jul;97 Suppl 1(Suppl 1):39-42.