输血可使习惯性流产女性产生/增加先前不存在/较弱的封闭抗体。

Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.

作者信息

Unander A M, Lindholm A, Olding L B

出版信息

Fertil Steril. 1985 Dec;44(6):766-71. doi: 10.1016/s0015-0282(16)49035-7.

Abstract

Women who suffered recurrent spontaneous abortions of unknown cause were studied for cellular reactivity and blocking antibody in a one-way mixed lymphocyte culture. A defined group of 20 women whose serum displayed no blocking capacity was given three transfusions of leukocyte-rich erythrocyte concentrates. Serum from all women displayed significant blocking capacity 2 months after the third transfusion. Because blocking antibody seems to be one of the necessary prerequisites for successful pregnancy, leukocyte transfusions from third-party donors ought to be an effective cure for habitual abortion in selected cases.

摘要

对原因不明的复发性自然流产女性进行单向混合淋巴细胞培养中的细胞反应性和封闭抗体研究。选定一组20名血清无封闭能力的女性，给予三次富含白细胞的红细胞浓缩物输血。在第三次输血后2个月，所有女性的血清均显示出显著的封闭能力。由于封闭抗体似乎是成功妊娠的必要先决条件之一，因此来自第三方供体的白细胞输血在特定病例中应该是习惯性流产的一种有效治疗方法。