Taylor C G, Faulk W P, McIntyre J A
J R Soc Med. 1985 Aug;78(8):623-7. doi: 10.1177/014107688507800804.
One hundred and thirty-nine couples referred because of recurrent abortions with no obvious cause were assessed for genetic similarity using the HLA major histocompatibility system. Comparison with 103 fertile control couples demonstrated that a much higher proportion of couples in the abortion group shared two or more HLA antigens. Using this criterion, 44 wives out of the 139 couples referred, when compared with a child-bearing group, appeared to share a greater than expected number of histocompatibility antigens and were therefore considered suitable for treatment. Twenty-eight wives have received treatment with white cell infusions from erythrocyte-compatible donors and so far they have delivered 17 babies plus 2 second babies. Another 3 wives are pregnant beyond their previous dates for abortions (1 first and 2 second pregnancies). There have been 5 failures (4 first pregnancy and 1 second pregnancy); one of these was treated a second time and has now successfully delivered. Seven couples are awaiting conception. Of the patients who have become pregnant, 81.5% have had successful deliveries. No adverse transfusion reactions have been observed.
对139对因不明原因反复流产前来就诊的夫妇，利用人类白细胞抗原（HLA）主要组织相容性系统评估其基因相似性。与103对有生育能力的对照夫妇相比，流产组中共有两个或更多HLA抗原的夫妇比例要高得多。按照这一标准，在前来就诊的139对夫妇中，与生育组相比，44名妻子似乎共有超过预期数量的组织相容性抗原，因此被认为适合治疗。28名妻子接受了来自红细胞相容供体的白细胞输注治疗，到目前为止，她们已产下17名婴儿，还有2名是二胎。另有3名妻子的怀孕时间超过了她们之前流产时的孕周（1名第一胎和2名第二胎）。有5例失败（4例第一胎和1例第二胎）；其中1例接受了第二次治疗，现已成功分娩。7对夫妇正在等待受孕。在已怀孕的患者中，81.5%成功分娩。未观察到不良输血反应。
