School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China.
Department of Dermatology, Naval Special Medical Center, Naval Medical University, Shanghai, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 May-Jun;16(3):e1964. doi: 10.1002/wnan.1964.
The shapes of micro- and nano-products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning and electrospraying, are facile in manipulate their products' shapes. In this review, the shapes generated using EHDA for modifying drug release profiles are reviewed. These shapes include linear nanofibers, round micro-/nano-particles, and beads-on-a-string hybrids. They can be further divided into different kinds of sub-shapes, and can be explored for providing the desired pulsatile release, sustained release, biphasic release, delayed release, and pH-sensitive release. Additionally, the shapes resulted from the organizations of electrospun nanofibers are discussed for drug delivery, and the shapes and inner structures can be considered together for developing novel drug delivery systems. In future, the shapes and the related shape-performance relationships at nanoscale, besides the size, inner structure and the related structure-performance relationships, would further play their important roles in promoting the further developments of drug delivery field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
微纳产品的形状对其功能性能有深远影响，但在过去几十年中，这一问题并未得到足够的重视。静电纺丝和电喷雾等电动力学雾化技术在操控产品形状方面具有很大的优势。本综述主要讨论了利用 EHDA 技术来改变药物释放曲线的各种形状，包括线性纳米纤维、圆形微/纳米颗粒和串珠状混合体。这些形状可以进一步分为不同的亚型，并可用于探索具有理想脉冲释放、持续释放、双相释放、延迟释放和 pH 敏感性释放等功能的药物。此外，还讨论了静电纺丝纳米纤维的组织形状在药物传递中的应用，并且可以综合考虑形状和内部结构来开发新型药物传递系统。在未来，纳米级的形状及其相关的性能关系，除了尺寸、内部结构和相关的结构-性能关系外，将在促进药物传递领域的进一步发展方面发挥重要作用。本文属于以下类别：治疗方法和药物发现 > 新兴技术。
