拓展用于亚砜对映选择性绿色合成的拜耳-维利格氧化反应和黄素单加氧酶生物催化剂的工具库。
Expanding the toolbox of Baeyer-Villiger and flavin monooxygenase biocatalysts for the enantiodivergent green synthesis of sulfoxides.
作者信息
Wu Jingyue, Anselmi Silvia, Carvalho Alexandra T P, Caswell Jill, Quinn Derek J, Moody Thomas S, Castagnolo Daniele
机构信息
Department of Chemistry, University College London 20 Gordon Street WC1H 0AJ London UK
Department of Biocatalysis & Isotope Chemistry Almac 20 Seagoe Industrial Estate Craigavon BT63 5QD UK
出版信息
Green Chem. 2024 Jul 5;26(15):8685-8693. doi: 10.1039/d4gc02657h. eCollection 2024 Jul 29.
Two new monooxygenase biocatalysts, the Baeyer-Villiger monooxygenase BVMO145 and the flavin monooxygenase FMO401 from Almac library, have been found to catalyse the enantiodivergent oxidation of sulfides bearing N-heterocyclic substituents into sulfoxides under mild and green conditions. The biocatalyst BVMO145 provides ()-sulfoxides while the flavin monooxygenase FMO401 affords ()-sulfoxides with good conversions and high ee.
已发现两种新型单加氧酶生物催化剂，即来自阿尔马克文库的拜耳-维利格单加氧酶BVMO145和黄素单加氧酶FMO401，可在温和且绿色的条件下催化含N-杂环取代基的硫化物对映选择性氧化为亚砜。生物催化剂BVMO145生成（）-亚砜，而黄素单加氧酶FMO401则能提供具有良好转化率和高对映体过量值的（）-亚砜。
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