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用于药物递送的铁酸亚铁包被的聚乙二醇化金红石型二氧化钛纳米颗粒：伊马替尼释放的评估

FericipXT-coated PEGylated rutile TiO nanoparticles in drug delivery: assessment of imatinib release.

作者信息

Bhullar Shilpy, Goyal Navdeep, Gupta Shikha

机构信息

Department of Physics, Centre of Advanced Study in Physics, Panjab University Chandigarh India.

Schepens Eye Research Institute (MEEI - Harvard Medical School) Boston Massachusetts USA

出版信息

RSC Adv. 2024 Jul 30;14(33):23886-23901. doi: 10.1039/d4ra02439g. eCollection 2024 Jul 26.

DOI:10.1039/d4ra02439g
PMID:39081656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11288344/
Abstract

This study presents a facile synthesis strategy for magnetic field-responsive PEGylated iron-supplement-coated rutile titanium dioxide (TiO) nanoparticles (NPs) for stimulus-responsive drug delivery. Imatinib, an anticancer drug, was successfully loaded into NPs, and its release was investigated under different pH conditions. XRD analysis confirmed the successful synthesis of PEGylated iron supplement-coated rutile titania NPs. HR-TEM studies revealed an increased NP size due to the coating, PEGylation, and drug loading, which was corroborated by FTIR spectra, confirming the drug loading into the NPs. DLS provided a hydrodynamic diameter of 642.2 nm and polydispersity index of 0.277 for PEGylated NPs, indicating their enhanced biodistribution and narrow size distribution. PEGylated NPs exhibited a negative zeta potential of -32.89 mV, indicating high stability. drug-release studies demonstrated controlled release with maximum efficiency under acidic conditions. Hemolysis assay confirmed the safety and biocompatibility of PEGylated NPs. All drug-loaded nanoformulations followed the Peppas-Sahlin model, suggesting Fickian diffusion and Case II relaxation mechanism of drug release. These NPs have the potential for the targeted delivery and controlled release of chemotherapeutics, thereby minimizing side effects.

摘要

本研究提出了一种简便的合成策略，用于制备用于刺激响应性药物递送的磁场响应性聚乙二醇化铁补充剂包覆的金红石型二氧化钛（TiO）纳米颗粒（NPs）。抗癌药物伊马替尼成功负载到纳米颗粒中，并在不同pH条件下研究了其释放情况。XRD分析证实了聚乙二醇化铁补充剂包覆的金红石型二氧化钛纳米颗粒的成功合成。高分辨透射电子显微镜研究表明，由于包覆、聚乙二醇化和药物负载，纳米颗粒尺寸增大，傅里叶变换红外光谱证实了这一点，确认了药物负载到纳米颗粒中。动态光散射法测得聚乙二醇化纳米颗粒的流体动力学直径为642.2 nm，多分散指数为0.277，表明其生物分布增强且尺寸分布狭窄。聚乙二醇化纳米颗粒的zeta电位为-32.89 mV，呈负值，表明具有高稳定性。药物释放研究表明，在酸性条件下药物能以最高效率实现控释。溶血试验证实了聚乙二醇化纳米颗粒的安全性和生物相容性。所有载药纳米制剂均符合Peppas-Sahlin模型，表明药物释放存在菲克扩散和Case II松弛机制。这些纳米颗粒具有靶向递送和控制释放化疗药物的潜力，从而将副作用降至最低。

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