McKimmie Ancelin, Keeves Jemma, Gadowski Adelle, Bagg Matthew K, Antonic-Baker Ana, Hicks Amelia J, Hill Regina, Clarke Nyssa, Holland Andrew, Veitch Bill, Fatovich Daniel, Reeder Sandy, Romero Lorena, Ponsford Jennie L, Lannin Natasha A, O'Brien Terence J, Cooper D Jamie, Rushworth Nick, Fitzgerald Melinda, Gabbe Belinda J, Cameron Peter A
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia.
Neurotrauma Rep. 2024 Jul 4;5(1):0. doi: 10.1089/neur.2023.0111. eCollection 2024.
The aim of the Australian Traumatic Brain Injury Initiative (AUS-TBI) is to design a data dictionary to inform data collection and facilitate prediction of outcomes for moderate-severe traumatic brain injury (TBI) across Australia. The process has engaged diverse stakeholders across six areas: social, health, clinical, biological, acute interventions, and long-term outcomes. Here, we report the results of the clinical review. Standardized searches were implemented across databases to April 2022. English-language reports of studies evaluating an association between a clinical factor and any clinical outcome in at least 100 patients with moderate-severe TBI were included. Abstracts, and full-text records, were independently screened by at least two reviewers in Covidence. The findings were assessed through a consensus process to determine inclusion in the AUS-TBI data resource. The searches retrieved 22,441 records, of which 1137 were screened at full text and 313 papers were included. The clinical outcomes identified were predominantly measures of survival and disability. The clinical predictors most frequently associated with these outcomes were the Glasgow Coma Scale, pupil reactivity, and blood pressure measures. Following discussion with an expert consensus group, 15 were recommended for inclusion in the data dictionary. This review identified numerous studies evaluating associations between clinical factors and outcomes in patients with moderate-severe TBI. A small number of factors were reported consistently, however, how and when these factors were assessed varied. The findings of this review and the subsequent consensus process have informed the development of an evidence-informed data dictionary for moderate-severe TBI in Australia.
澳大利亚创伤性脑损伤倡议（AUS-TBI）的目标是设计一个数据字典，为全澳大利亚中重度创伤性脑损伤（TBI）的数据收集提供信息，并促进对其预后的预测。该过程涉及社会、健康、临床、生物学、急性干预和长期预后六个领域的不同利益相关者。在此，我们报告临床审查的结果。截至2022年4月，在各数据库中进行了标准化检索。纳入了至少100例中重度TBI患者中评估临床因素与任何临床结局之间关联的英文研究报告。摘要和全文记录由Covidence中至少两名审阅者独立筛选。通过共识过程对研究结果进行评估，以确定是否纳入AUS-TBI数据资源。检索到22441条记录，其中1137条进行了全文筛选，313篇论文被纳入。确定的临床结局主要是生存和残疾指标。与这些结局最常相关的临床预测因素是格拉斯哥昏迷量表、瞳孔反应性和血压测量值。在与专家共识小组讨论后，建议将15项纳入数据字典。这项审查确定了大量评估中重度TBI患者临床因素与结局之间关联的研究。然而，虽然有少数因素被一致报道，但这些因素的评估方式和时间各不相同。本次审查的结果以及随后的共识过程为澳大利亚中重度TBI的循证数据字典的制定提供了依据。
