Cline Trevor L, Morfini Francesca, Tinney Emma, Makarewycz Ethan, Lloyd Katherine, Olafsson Valur, Bauer Clemens C C, Kramer Arthur F, Raine Lauren B, Gabard-Durnam Laurel J, Whitfield-Gabrieli Susan, Hillman Charles H
Department of Psychology, Northeastern University, Boston, MA, USA.
Center for Cognitive & Brain Health, Northeastern University, Boston, MA.
Brain Plast. 2024 May 14;9(1-2):5-20. doi: 10.3233/BPL-240003. eCollection 2024.
A single bout of aerobic exercise can provide acute benefits to cognition and emotion in children. Yet, little is known about how acute exercise may impact children's underlying brain networks' resting-state functional connectivity (rsFC).
Using a data-driven multivariate pattern analysis, we investigated the effects of a single dose of exercise on acute rsFC changes in 9-to-13-year-olds.
On separate days in a crossover design, participants ( = 21) completed 20-mins of acute treadmill walking at 65-75% heart rate maximum (exercise condition) and seated reading (control condition), with pre- and post-fMRI scans. Multivariate pattern analysis was used to investigate rsFC change between conditions.
Three clusters in the left lateral prefrontal cortex (lPFC) of the frontoparietal network (FPN) had significantly different rsFC after the exercise condition compared to the control condition. Post-hoc analyses revealed that from before to after acute exercise, activity of these FPN clusters became more correlated with bilateral lPFC and the left basal ganglia. Additionally, the left lPFC became more anti-correlated with the precuneus of the default mode network (DMN). An opposite pattern was observed from before to after seated reading.
The findings suggest that a single dose of exercise increases connectivity within the FPN, FPN integration with subcortical regions involved in movement and cognition, and segregation of FPN and DMN. Such patterns, often associated with healthier cognitive and emotional control, may underlie the transient mental benefits observed following acute exercise in youth.
单次有氧运动可为儿童的认知和情绪带来即时益处。然而，关于急性运动如何影响儿童潜在脑网络的静息态功能连接（rsFC），我们知之甚少。
使用数据驱动的多变量模式分析，我们研究了单次运动剂量对9至13岁儿童急性rsFC变化的影响。
在交叉设计的不同日期，参与者（n = 21）在最大心率的65 - 75%下完成20分钟的急性跑步机行走（运动条件）和坐着阅读（对照条件），并在功能磁共振成像扫描前后进行。多变量模式分析用于研究不同条件之间的rsFC变化。
与对照条件相比，运动条件后额顶网络（FPN）左侧外侧前额叶皮质（lPFC）中的三个簇的rsFC有显著差异。事后分析显示，从急性运动前到运动后，这些FPN簇的活动与双侧lPFC和左侧基底神经节的相关性更强。此外，左侧lPFC与默认模式网络（DMN）的楔前叶的反相关性增强。坐着阅读前后观察到相反的模式。
研究结果表明，单次运动剂量增加了FPN内的连接性、FPN与参与运动和认知的皮质下区域的整合，以及FPN和DMN的分离。这些模式通常与更健康的认知和情绪控制相关，可能是青少年急性运动后观察到的短暂心理益处的基础。
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