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姜黄素的启示：化学、生物合成及治疗潜力的全面综述。

Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials.

机构信息

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, 47500, Malaysia.

Department of Parasitology & Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, Malaysia.

出版信息

Drug Des Devel Ther. 2024 Jul 26;18:3295-3313. doi: 10.2147/DDDT.S463545. eCollection 2024.

DOI:10.2147/DDDT.S463545
PMID:39081702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11288359/
Abstract

Lawsone, a naturally occurring organic compound also called hennotannic acid, obtained mainly from (Henna). It is a potential drug-like molecule with unique chemical and biological characteristics. Traditionally, henna is used in hair and skin coloring and is also a medicinal herb for various diseases. It is also widely used as a starting material for the synthesis of various drug molecules. In this review, we investigate on the chemistry, biosynthesis, physical and biological properties of lawsone. The results showed that lawsone has potential antioxidant, anti-inflammatory, antimicrobial and antitumor properties. It also induces cell cycle inhibition and programmed cell death in cancer, making it a potential chemotherapeutic agent. Additionally, inhibition of pro-inflammatory cytokine production makes it an essential treatment for inflammatory diseases. Exploration of its biosynthetic pathway can pave the way for its development into targets for new drug development. In future, well-thought-out clinical studies should be made to verify its safety and efficacy.

摘要

龙葵素，一种天然存在的有机化合物，也称为鞣花酸，主要从 （指甲花）中提取。它是一种具有独特化学和生物学特性的潜在药物样分子。传统上，指甲花用于头发和皮肤染色，也是治疗各种疾病的草药。它也被广泛用作合成各种药物分子的起始材料。在这篇综述中，我们研究了龙葵素的化学、生物合成、物理和生物学特性。结果表明，龙葵素有潜在的抗氧化、抗炎、抗菌和抗肿瘤特性。它还能诱导癌细胞的细胞周期抑制和程序性细胞死亡，使其成为一种潜在的化疗药物。此外，抑制促炎细胞因子的产生使其成为治疗炎症性疾病的重要手段。对其生物合成途径的探索可以为其开发成为新药靶点铺平道路。未来，应该进行深思熟虑的临床研究来验证其安全性和疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/74d11f504bbc/DDDT-18-3295-g0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/7a51a8eef566/DDDT-18-3295-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/efcd2f2c3e83/DDDT-18-3295-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/d76ad6e2e4b4/DDDT-18-3295-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/19079d40a63f/DDDT-18-3295-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/74d11f504bbc/DDDT-18-3295-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/1ea3c9a32073/DDDT-18-3295-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/167c9f6336b5/DDDT-18-3295-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/d540c54a780f/DDDT-18-3295-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/629ac7f2a16a/DDDT-18-3295-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/5b3536377900/DDDT-18-3295-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/7a51a8eef566/DDDT-18-3295-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/efcd2f2c3e83/DDDT-18-3295-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/d76ad6e2e4b4/DDDT-18-3295-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/19079d40a63f/DDDT-18-3295-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623a/11288359/74d11f504bbc/DDDT-18-3295-g0010.jpg

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