阿联酋成年人阻塞性睡眠呼吸暂停风险与 2 型糖尿病的相关性：来自阿联酋健康未来研究的结果。

Association between obstructive sleep apnea risk and type 2 diabetes among Emirati adults: results from the UAE healthy future study.

机构信息

Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.

Department of Medicine, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.

出版信息

Front Endocrinol (Lausanne). 2024 Jul 16;15:1395886. doi: 10.3389/fendo.2024.1395886. eCollection 2024.

DOI:10.3389/fendo.2024.1395886

PMID:39081790

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11286458/

Abstract

INTRODUCTION

Obstructive sleep apnea (OSA) can have negative impacts on the health outcomes of individuals with type 2 diabetes. However, in the United Arab Emirates (UAE), there is a lack of understanding regarding the relationship between OSA and type 2 diabetes despite the significant implications it has on health. The primary objective of this study is to investigate the association between OSA risk and type 2 diabetes, associated risk factors, and gender differences in OSA symptoms among Emirati adults.

METHODS

We conducted a cross-sectional analysis of the baseline data from the UAE Healthy Future Study (UAEHFS) collected between February 2016 and March 2023. Our sample consisted of 4578 participants aged 18-71 who completed the STOP-BANG survey, provided body measurements and blood samples. We stratified the patients according to their OSA risk and diabetes. We used univariate and multivariate logistic regression models to analyze the relationship between OSA risk and type 2 diabetes and to identify factors associated with risk for OSA and type 2 diabetes. We estimated odds ratios (ORs) with corresponding 95% confidence intervals (95% CI).

RESULTS

The mean age was 27.5 years (± 8.35), and 55.81% (n=2555) were men. The overall prevalence of high risk for OSA was 16.58% and was higher in men compared to women (26.46% vs 4.10%). Women reported feeling tired more often than men (68.02% vs 48.96%). Both genders have similar rates of stop breathing and BMI ≥ 35. There was a significant association between the OSA risk and type 2 diabetes in the unadjusted model (OR=2.44; 95% CI: 1.78-3.35; p-value <0.0001) and (OR=6.44; 95% CI: 4.32-9.59; p-value < 0.0001) among those who reported intermediate and high OSA risk, respectively. After adjusting the model for education attainment, marital status, waist circumference, and smoking, the association remained significant between diabetes and OSA risk, with an OR of 1.65 (95%CI: 1.18-2.32; p-value =0.004) for intermediate OSA risk and 3.44 (95%CI: 2.23-5.33; p-value <0.0001) for high OSA risk.

CONCLUSIONS

This study conducted in the UAE found a significant correlation between OSA risk and type 2 diabetes. We suggest introducing routine screening of OSA for individuals with diabetes.

摘要

介绍

阻塞性睡眠呼吸暂停（OSA）会对 2 型糖尿病患者的健康结果产生负面影响。然而，在阿拉伯联合酋长国（阿联酋），尽管 OSA 对健康有重大影响，但人们对 OSA 与 2 型糖尿病之间的关系缺乏了解。本研究的主要目的是调查 OSA 风险与 2 型糖尿病、相关风险因素以及阿联酋成年人中 OSA 症状的性别差异之间的关联。

方法

我们对 2016 年 2 月至 2023 年 3 月期间阿联酋健康未来研究（UAEHFS）的基线数据进行了横断面分析。我们的样本包括 4578 名年龄在 18-71 岁之间的参与者，他们完成了 STOP-BANG 调查，提供了身体测量和血液样本。我们根据 OSA 风险和糖尿病对患者进行分层。我们使用单变量和多变量逻辑回归模型来分析 OSA 风险与 2 型糖尿病之间的关系，并确定与 OSA 和 2 型糖尿病风险相关的因素。我们估计了比值比（OR）及其相应的 95%置信区间（95%CI）。

结果

平均年龄为 27.5 岁（±8.35），55.81%（n=2555）为男性。OSA 高风险的总体患病率为 16.58%，男性高于女性（26.46%比 4.10%）。女性比男性更常感到疲倦（68.02%比 48.96%）。两种性别停止呼吸和 BMI≥35 的发生率相似。在未调整模型中，OSA 风险与 2 型糖尿病之间存在显著关联（OR=2.44；95%CI：1.78-3.35；p 值<0.0001），在报告中、高度 OSA 风险的患者中，分别为（OR=6.44；95%CI：4.32-9.59；p 值<0.0001）。在调整教育程度、婚姻状况、腰围和吸烟状况的模型后，糖尿病与 OSA 风险之间的关联仍然显著，中 OSA 风险的 OR 为 1.65（95%CI：1.18-2.32；p 值=0.004），高 OSA 风险的 OR 为 3.44（95%CI：2.23-5.33；p 值<0.0001）。