Robust anti-tubercular profile of extract in enhancing isoniazid bioavailability and curtailing stress tolerance in .

INTRODUCTION

The formidable survival mechanisms employed by (), combined with the low bioavailability of anti-tubercular drugs and their associated hepatotoxicity, worsen tuberculosis management. Traditional medicinal plants offer potential solutions to these challenges. This study focuses on exploring the anti-tubercular potential of against , .

METHODS AND RESULTS

HPTLC and UHPLC phytochemically characterized the hydro-methanolic extract of (SVE). SVE curtails the growth and viability of under normal and stress conditions. The compromised cell wall integrity of with SVE is depicted through scanning electron microscopy (SEM) while EtBr permeability assays and TLC-based comparative changes in lipids extraction addressed the integrity of the cell wall. Furthermore, SVE augmented the susceptibility of towards Isoniazid (INH) through enhanced bioavailability. Adjunct treatment of SVE with INH demonstrated a markedly reduced survival of the intracellular bacilli. The study also uncovered the hepatoprotective potential of SVE in HepG2 cells.

CONCLUSION

This research paves the way for deeper exploration into the potential of against virulent strains, emphasizing over the significance of traditional medicinal plants in tuberculosis treatment. Collectively, the findings suggest SVE as a potent candidate for independent or adjunct anti-tubercular therapy.