尼达尼布治疗症状性放射性肺炎。病例报告。
Nintedanib for the treatment of symptomatic radiation pneumonitis. A Case Report.
作者信息
Kuipers M E, Van Doorn-Wink K C J, Postmus P E
机构信息
Leiden University Medical Center (LUMC), Department of Pulmonology, C02-Q, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
Leiden University Medical Center (LUMC), Department of Radiotherapy, K01-P, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
出版信息
Heliyon. 2024 Jul 9;10(14):e34345. doi: 10.1016/j.heliyon.2024.e34345. eCollection 2024 Jul 30.
Radiation induced pneumonitis is a common side effect of thoracic radiotherapy. We report a case of a patient diagnosed with symptomatic radiation pneumonitis and a serious contra-indication for corticosteroids. For that reason, the patient was treated with nintedanib instead. After several weeks of treatment her symptoms and chest CT improved significantly. This case shows that nintedanib might be an effective treatment of radiation pneumonitis if corticosteroids are contra-indicated.
放射性肺炎是胸部放疗常见的副作用。我们报告一例被诊断为有症状放射性肺炎且有使用皮质类固醇严重禁忌证的患者。因此，该患者改用尼达尼布治疗。经过几周治疗，她的症状和胸部CT有显著改善。该病例表明，如果皮质类固醇有禁忌证，尼达尼布可能是治疗放射性肺炎的有效药物。
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