Maluleke Tirhani, Benecke Rohan, Oladejo Sunday, Feulner Georg, Kern Steve, Lister Johanna, McClelland Gabriel, Njoki Miriam, Noack Patrick, Petruccione Francesco, Rajaratnam Kanshukan, Waitt Catriona, Rosenkranz Bernd, Pillai Goonaseela
F. Hoffmann La-Roche, Johannesburg, South Africa.
Fundisa African Academy of Medicines Development, Cape Town, South Africa.
Br J Clin Pharmacol. 2024 Oct;90(10):2509-2516. doi: 10.1111/bcp.16192. Epub 2024 Jul 31.
Clinical pharmacology is often the nexus in any cross-disciplinary team that is seeking solutions for human healthcare issues. The use and application of real-world data and artificial intelligence to better understand our ecosystem has influenced our view at the world and how we do things. This has resulted in remarkable advancements in the healthcare space and development of personalized medicines with great attributes from the application of models and simulations, contributing to a more efficient healthcare development process. A cross-disciplinary symposium was held in December 2023, whereby experts from different scientific disciplines engaged in a high-level discussion on the opportunities and challenges of mathematical models in different fields, possible future developments and decision making. A strong interlink amongst the disciplines represented was apparent, with clinical pharmacology identified as the one which integrates various scientific disciplines. Deliberate and strategic cross-disciplinary dialogues are required to break out of the silos and implement integration for efficiency and cost-effectiveness of novel interventions.
临床药理学往往是任何一个为人类医疗保健问题寻求解决方案的跨学科团队的核心。利用和应用真实世界数据与人工智能以更好地理解我们的生态系统，已经影响了我们对世界的看法以及我们做事的方式。这在医疗保健领域带来了显著进展，并通过模型和模拟的应用开发出了具有卓越特性的个性化药物，推动了更高效的医疗保健开发进程。2023年12月举办了一次跨学科研讨会，来自不同科学学科的专家就数学模型在不同领域的机遇与挑战、可能的未来发展以及决策进行了高层次讨论。所代表的各学科之间存在明显的紧密联系，临床药理学被视为整合各种科学学科的学科。需要进行深思熟虑且具有战略意义的跨学科对话，以打破壁垒并实现整合，从而提高新型干预措施的效率和成本效益。
