Li Xing-Yao, Chen Rui-Sheng, Li Guo-Chang, Du Kai-Cheng, Lai Lan-Tao, Wang Yu-Meng, Meng Da-Li
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
J Asian Nat Prod Res. 2025 May;27(5):658-668. doi: 10.1080/10286020.2024.2385370. Epub 2024 Jul 31.
Four new lycoctonine-type C-diterpenoid alkaloids kamaonensines H-K () have been isolated from the whole plants of , together with 12 known compounds (). Interestingly, kamaonensines contained a rare nitrone (immine N-oxide) moiety, respectively. Their structures were established by spectroscopic analyses. The active evaluation of compounds () by LPS induced RAW 264.7 macrophages showed that compounds and displayed strong anti-inflammatory activities. While compounds and also showed strong cytotoxicities by the RAW 264.7 cell viability assay.
从[植物名称]的全草中分离出了4种新的牛扁碱型C-二萜生物碱卡马宁H-K（），以及12种已知化合物（）。有趣的是，卡马宁分别含有一个罕见的硝酮（亚胺N-氧化物）部分。通过光谱分析确定了它们的结构。对化合物（）进行LPS诱导的RAW 264.7巨噬细胞活性评估表明，化合物[具体化合物编号]和[具体化合物编号]表现出较强的抗炎活性。而通过RAW 264.7细胞活力测定，化合物[具体化合物编号]和[具体化合物编号]也表现出较强的细胞毒性。
