State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, 510632.
Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632.
Chem Biodivers. 2024 Feb;21(2):e202301958. doi: 10.1002/cbdv.202301958. Epub 2024 Jan 24.
Three novel diterpenoid alkaloids, comprising two C -diterpenoid alkaloids (1 and 2) and one C -diterpenoid alkaloid (3), were isolated from Delphinium ajacis, alongside the six known compounds (4-9). Their structures were elucidated by spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and chemical properties. Simultaneously, the anti-inflammatory properties of all compounds (1-9) was conducted, focusing on nitric oxide (NO) production in LPS-induced BV-2 cells. The results indicated compounds 1-3, 7, and 8 have potential anti-inflammatory activity.
从翠雀中分离得到了三个新的二萜生物碱，包括两个 C-二萜生物碱（1 和 2）和一个 C-二萜生物碱（3），以及六个已知化合物（4-9）。通过光谱方法（MS、UV、IR、1D 和 2D NMR）和化学性质对它们的结构进行了阐明。同时，对所有化合物（1-9）的抗炎活性进行了研究，重点是 LPS 诱导的 BV-2 细胞中一氧化氮（NO）的产生。结果表明，化合物 1-3、7 和 8 具有潜在的抗炎活性。
