Diagnostic and Functional Neuroradiology and Brain Stimulation Department - Clinical Investigation Center 1423, 15-20 National Vision Hospital, University of Paris-Saclay - UVSQ, 28, Rue de Charenton, Paris, 75012, France.
Laboratory of Mathematics and Applications (LMA) CNRS 7348, LRCOM i3M -DACTIM-MIS (Data Analysis and Computations Through Imaging Modeling Mathematics, University of Poitiers, Poitiers, France.
Graefes Arch Clin Exp Ophthalmol. 2024 Dec;262(12):3867-3879. doi: 10.1007/s00417-024-06544-4. Epub 2024 Jul 31.
To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.
A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA), start (FA) and end (FA) of laminar flow, and arterial time (ICGA), respectively. OCT angiography VDs were superficial (VD) and deep (VD) RCPs and CC (VD) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD and VD were significantly inversely correlated with FA, FA and FA likewise VD with ICGA. Correlations were stronger in patients without CVR than with CVR. CVR, FA, FA and FA were more strongly correlated with VD than VD. FA, FA and FA significantly impacted VD and VD, likewise ICGA impacted VD. VD was most strongly impacted by FA and FA.
Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
强调眼前期和眼内血管循环动力学对伴有和不伴有心血管风险（CVR）因素的患者视网膜毛细血管丛（RCP）和脉络膜毛细血管（CC）血管密度（VD）的影响。
这是一项回顾性观察研究，纳入了伴有和不伴有 CVR 因素（1 型和 2 型糖尿病、动脉高血压和高胆固醇血症）的患者。荧光素（FA）和吲哚菁绿（ICGA）血管造影循环时间分别为动脉时间（FA）、层流开始（FA）和结束（FA）以及动脉时间（ICGA）。OCT 血管造影 VD 包括浅层（VD）和深层（VD）RCP 和 CC（VD）VD。在调整混杂因素后进行相关性和回归分析。
共纳入 177 例患者的 177 只眼（平均年龄：65.2±15.9 岁，n=92 例伴有和 85 例不伴有 CVR）。VD 和 VD 与 FA 呈显著负相关，FA 和 FA 同样与 VD 呈负相关。在不伴有 CVR 的患者中，相关性比伴有 CVR 的患者更强。CVR、FA、FA 和 FA 与 VD 的相关性比 VD 更强。FA、FA 和 FA 显著影响 VD 和 VD，同样 ICGA 也影响 VD。FA 和 FA 对 VD 的影响最大。
眼前期和眼内循环动力学对 RCP 和 CC VD 有显著影响，尤其是深层 RCP。
