Al-Sheikh Mayss, Phasukkijwatana Nopasak, Dolz-Marco Rosa, Rahimi Mansour, Iafe Nicholas A, Freund K Bailey, Sadda SriniVas R, Sarraf David
Doheny Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 2Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 3Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2063-2069. doi: 10.1167/iovs.16-21289.
To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using quantitative optical coherence tomography angiography (OCTA) analysis.
Macular OCTA images of 3 × 3 mm were obtained using the RTVue-XR Avanti with AngioVue. Quantitative measurements of the retinal capillary microvascular layers and the CC were analyzed using en face projection images. Vessel density and fractal dimension of the superficial and deep retinal capillary plexus, and area and density of flow reduction in the CC were analyzed, quantified, and compared with an age-matched control group.
Fifty eyes with myopia and 34 age-matched healthy eyes were included in this study. The vessel density and the vessel branching complexity using fractal dimension of the retinal capillary microvasculature were significantly lower in myopic eyes (P < 0.001 and P = 0.001). The total number of flow voids in the CC was lower (108.93 vs. 138.63, P = 0.001) but the total and average flow void area was significantly higher (total area 3.715 ± 0.257 vs. 3.596 ± 0.194 mm2, P = 0.026; average area 0.044 ± 0.029 vs. 0.028 ± 0.010 mm2, P = 0.002) compared with the healthy control group. Average choroidal thickness was lower in the myopic group versus the normal control cohort (123.538 ± 73.477 vs. 246.97 ± 41.745 μm, P < 0.05) and significantly reduced in eyes with lacquer cracks (LC) compared with myopic eyes without LC formation (P = 0.003). There was no correlation between choroidal thickness and quantitative parameters of the CC in the myopic eyes.
The density of the retinal capillary microvasculature is reduced and the area of flow deficit in the CC is increased in eyes with greater myopia. The relevance of microvascular alterations in the setting of myopia warrants further study.
使用定量光学相干断层扫描血管造影（OCTA）分析来研究近视眼的视网膜毛细血管微脉管系统和脉络膜毛细血管（CC）。
使用配备AngioVue的RTVue-XR Avanti获取3×3mm的黄斑OCTA图像。使用正面投影图像对视网膜毛细血管微脉管层和CC进行定量测量。分析、量化并与年龄匹配的对照组比较浅层和深层视网膜毛细血管丛的血管密度和分形维数，以及CC中血流减少的面积和密度。
本研究纳入了50只近视眼和34只年龄匹配的健康眼。近视眼视网膜毛细血管微脉管系统的血管密度和使用分形维数表示的血管分支复杂性显著降低（P<0.001和P = 0.001）。与健康对照组相比，CC中血流缺失的总数较低（108.93对138.63，P = 0.001），但血流缺失的总面积和平均面积显著更高（总面积3.715±0.257对3.596±0.194mm²，P = 0.026；平均面积0.044±0.029对0.028±0.010mm²，P = 0.002）。近视组的平均脉络膜厚度低于正常对照组（123.538±73.477对246.97±41.745μm，P<0.05），与无漆裂纹（LC）形成的近视眼相比，有LC的眼中脉络膜厚度显著降低（P = 0.003）。近视眼的脉络膜厚度与CC的定量参数之间无相关性。
高度近视眼中视网膜毛细血管微脉管系统的密度降低，CC中血流不足的面积增加。近视情况下微血管改变的相关性值得进一步研究。
