New York University Grossman School of Medicine, 550 1st Avenue, New York, NY, 10016, USA.
Department of Obstetrics and Gynecology, New York University, New York, NY, USA.
J Assist Reprod Genet. 2024 Oct;41(10):2807-2812. doi: 10.1007/s10815-024-03217-3. Epub 2024 Jul 31.
Prior to cancer treatment, patients make decisions on whether to undergo fertility preservation (FP) and the method of FP. We sought to learn more about counseling and decision-making on the method of cancer-related FP.
A cross-sectional 26-item online survey was administered to patients with ovaries who underwent cancer-related FP. Associations between demographics and the FP method were made through estimates of risk difference, with a 95% confidence interval. Open-ended responses were analyzed using the constant comparative method.
A total of 240 respondents completed the survey: 52% underwent oocyte cryopreservation (OC), 29% underwent embryo cryopreservation (EC), and 19% underwent both oocyte and embryo cryopreservation (OC/EC). Most respondents agreed that if they were to go through the process again, they would make the same decision about FP (80% EC, 72% OC, 59% OC/EC). Women ≥ 35 years reported being counseled more that embryos were superior compared to younger women (risk difference 46%, CI 32.8, 59.1), however were not more likely to freeze embryos (risk difference 6.2%, CI - 9.8, 22.2). Women in long-term relationships reported they were counseled more that embryos were superior compared to those single/dating (risk difference 27%, CI 18.1, 35.9). All women in long-term relationships reported undergoing EC, while the majority of single/dating women reported undergoing OC (74.6%).
Most women who have undergone cancer-related FP reported they would choose the same FP method again. Women in long-term relationships or ≥ 35 years reported they were more likely to be counseled that EC is superior; however, only women in long-term relationships were more likely to freeze embryos.
在癌症治疗前，患者需要决定是否进行生育力保存（FP）以及采用何种 FP 方法。我们旨在深入了解与癌症相关的 FP 方法的咨询和决策。
对接受癌症相关 FP 的卵巢患者进行了一项 26 项的横断面在线调查。通过风险差异估计，结合 95%置信区间，对人口统计学特征与 FP 方法之间的关系进行了评估。采用恒定比较法对开放式回答进行了分析。
共有 240 名受访者完成了调查：52%的患者选择了卵母细胞冷冻保存（OC），29%的患者选择了胚胎冷冻保存（EC），19%的患者选择了卵母细胞和胚胎冷冻保存（OC/EC）。大多数受访者表示，如果再次经历这个过程，他们会对 FP 做出相同的决定（80%的 EC、72%的 OC、59%的 OC/EC）。≥35 岁的女性报告说，她们被更多地告知胚胎优于年轻女性（风险差异 46%，CI 32.8，59.1），但她们不太可能冷冻胚胎（风险差异 6.2%，CI-9.8，22.2）。处于长期关系中的女性报告说，她们被更多地告知胚胎优于单身/约会的女性（风险差异 27%，CI 18.1，35.9）。所有处于长期关系中的女性都报告说进行了 EC，而大多数单身/约会的女性报告说进行了 OC（74.6%）。
大多数接受过癌症相关 FP 的女性表示，她们会再次选择相同的 FP 方法。处于长期关系中或≥35 岁的女性报告说，她们更有可能被告知 EC 更优越；然而，只有处于长期关系中的女性更有可能冷冻胚胎。
