抗白细胞介素-10 的中和自身抗体治疗炎症性肠病。
Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease.
机构信息
From the Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute (H.G., S.H.), and the Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust (P.S.L., E.W., A.M., A.J.C., S.H.), Newcastle upon Tyne, the Department of Clinical Biochemistry and Immunology, Cambridge University Hospital (L.C.-G., S.E., S.D., R.D.), and the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre (R.D.), Cambridge, the Translational Gastroenterology Unit (N.G., S.T., P.K., H.H.U.), the Kennedy Institute of Rheumatology (S.T.), the NIHR Oxford Biomedical Research Centre (S.T., P.K., H.H.U.), and the Department of Pediatrics (H.H.U.), University of Oxford, Oxford, the Department of Pediatric Gastroenterology, Royal Belfast Hospital for Sick Children (A.S., L.M.), and the Department of Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust (S.I.), Belfast, and the Department of Pediatric Gastroenterology, Royal Aberdeen Children's Hospital, Aberdeen (S.B.) - all in the United Kingdom; and the Pediatric Gastroenterology Department, Pál Heim National Pediatric Institute, Budapest, Hungary (A.S.).
出版信息
N Engl J Med. 2024 Aug 1;391(5):434-441. doi: 10.1056/NEJMoa2312302.
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an associated decrease in the anti-interleukin-10 titer, conventional IBD therapy could be withdrawn. A second child with neutralizing anti-interleukin-10 autoantibodies had a milder course of IBD and has been treated without B-cell depletion. We conclude that neutralizing anti-interleukin-10 autoantibodies may be a causative or modifying factor in IBD, with potential implications for therapy. (Funded by the National Institute for Health and Care Research and others.).
我们在一名儿童身上发现了针对白细胞介素-10 的高滴度中和自身抗体，该儿童患有婴儿起病炎症性肠病（IBD），这是白细胞介素-10 信号转导的先天性错误的表型。在 B 细胞耗竭治疗后，抗白细胞介素-10 滴度降低，可停止常规 IBD 治疗。第二例具有中和抗白细胞介素-10 自身抗体的儿童 IBD 病程较轻，且未进行 B 细胞耗竭治疗。我们的结论是，中和抗白细胞介素-10 自身抗体可能是 IBD 的致病或修饰因素，对治疗具有潜在意义。（由国家卫生与保健研究中心等资助）。
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