Department of Cardiology, Jinan Central Hospital, Shandong University, Jinan, China.
Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Int Immunopharmacol. 2024 Oct 25;140:112784. doi: 10.1016/j.intimp.2024.112784. Epub 2024 Jul 30.
Vascular remodeling is a dynamic process involving cellular and molecular changes, including cell proliferation, migration, apoptosis and extracellular matrix (ECM) synthesis or degradation, which disrupt the homeostasis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). Cigarette smoke exposure (CSE) is thought to promote vascular remodeling, but the components are complex and the mechanisms are unclear. In this review, we overview the progression of major components of cigarette smoke (CS), such as nicotine and acrolein, involved in vascular remodeling in terms of ECs injury, VSMCs proliferation, migration, apoptosis, and ECM disruption. The aim was to elucidate the effects of different components of CS on different cells of the vascular system, to discover the relevance of their actions, and to provide new references for future studies.
血管重构是一个涉及细胞和分子变化的动态过程，包括细胞增殖、迁移、凋亡和细胞外基质（ECM）的合成或降解，破坏了内皮细胞（EC）和血管平滑肌细胞（VSMC）的内稳态。吸烟暴露（CSE）被认为可促进血管重构，但成分复杂，机制尚不清楚。在这篇综述中，我们概述了香烟烟雾（CS）中的主要成分，如尼古丁和丙烯醛，如何通过损伤内皮细胞、促进血管平滑肌细胞增殖、迁移、凋亡和破坏细胞外基质来参与血管重构。目的是阐明 CS 的不同成分对血管系统不同细胞的影响，发现它们作用的相关性，并为未来的研究提供新的参考。
