Institute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, People's Republic of China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, People's Republic of China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, People's Republic of China; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei 430065, People's Republic of China.
J Hazard Mater. 2024 Sep 15;477:135220. doi: 10.1016/j.jhazmat.2024.135220. Epub 2024 Jul 16.
Current scientific knowledge is insufficient on the effects of metal mixtures on early life growth trajectories. This study included 7118 mother-infant pairs from a Chinese birth cohort. Concentrations of 18 maternal urinary metals were quantified, and growth trajectories were conducted based on standardized body mass index (BMI) for up to eight times from 0 to 2 years. A three-phase analytical framework was applied to explore the risk ratios (RR) and 95 % confidence intervals (95 % CI) of co-exposure to metals on dynamic growth, along with potential modifiers. Five growth trajectory groups were identified. Exposure to metal mixtures driven by thallium (Tl, 34.8 %) and aluminum (Al, 16.2 %) was associated with an increased risk of low-rising trajectory (RR=1.58, 95 % CI: 1.25, 2.00); however, exposure to mixtures driven by strontium (Sr, 49.5 %) exhibited an inverse correlation (RR = 0.81, 95 % CI: 0.67, 0.97). Furthermore, infants with varying levels of Tl, Al and Sr, as well as modifiers including pre-pregnancy BMI and infant sex faced distinct risks of low-rising trajectory. Our findings highlighted the Tl, Al, and Sr as key metals in relation to the low-rising trajectory in early life characterized as catch-up growth, with pre-pregnancy BMI and infant sex exerting as potential modifiers.
目前关于金属混合物对早期生命生长轨迹的影响的科学知识还不够充分。本研究纳入了一个中国出生队列中的 7118 对母婴对。定量检测了 18 种母体尿液金属的浓度，并基于标准化体重指数（BMI）对 0 至 2 岁期间最多 8 次的生长轨迹进行了研究。应用了一个三阶段分析框架来探索金属混合物共同暴露对动态生长的风险比（RR）和 95%置信区间（95%CI），以及潜在的修饰因子。确定了五个生长轨迹组。由铊（Tl，34.8%）和铝（Al，16.2%）驱动的金属混合物暴露与低上升轨迹的风险增加相关（RR=1.58，95%CI：1.25，2.00）；然而，由锶（Sr，49.5%）驱动的混合物暴露则表现出相反的相关性（RR=0.81，95%CI：0.67，0.97）。此外，具有不同 Tl、Al 和 Sr 水平的婴儿以及包括孕前 BMI 和婴儿性别在内的修饰因子面临着不同的低上升轨迹风险。我们的研究结果突出了 Tl、Al 和 Sr 是与生命早期低上升轨迹（表现为追赶生长）相关的关键金属，而孕前 BMI 和婴儿性别则是潜在的修饰因子。
