Department of Psychology, University of British Columbia, Vancouver V6T 1Z4, Canada.
Department of Psychology, University of British Columbia, Vancouver V6T 1Z4, Canada.
Psychoneuroendocrinology. 2024 Nov;169:107136. doi: 10.1016/j.psyneuen.2024.107136. Epub 2024 Jul 15.
Osteocalcin is a bone-derived hormone implicated in the acute stress response and recently linked to adult depression. Yet it is unclear whether osteocalcin is a biomarker of other forms of psychopathology and whether osteocalcin-psychopathology associations emerge during developmentally sensitive periods earlier in life. Thus, in the current pilot study we examined salivary osteocalcin and psychiatric symptoms and disorders among 48 early adolescents during a period of stress. A logistic regression indicated lower osteocalcin was associated with meeting criteria for a psychiatric disorder, OR = 0.43, 95 % CI [.002,.924], and showed moderate-to-large cross-sectional associations with a range of elevated psychopathology symptoms, Bs ≥ |-3.44|, ps ≤.034. Multilevel linear growth models indicated that low osteocalcin prospectively predicted an even greater range of psychopathology symptoms at one-year follow-up as well as increases in some symptoms over time, Bs ≥ |-1.83|, ps ≤.021. Findings introduce osteocalcin as a biomarker of diverse forms of psychopathology in youth. Osteocalcin is a potential transdiagnostic mechanism through which dysregulated responses to stress could cause or exacerbate various types of psychopathology, highlighting a promising target for clinical assessment and early intervention.
骨钙素是一种与急性应激反应有关的骨骼来源激素，最近与成人抑郁症有关。然而，目前尚不清楚骨钙素是否是其他形式精神病理学的生物标志物，以及骨钙素-精神病理学的关联是否在生命早期的发育敏感时期出现。因此，在目前的初步研究中，我们在压力期间检查了 48 名早期青少年的唾液骨钙素和精神症状和障碍。逻辑回归表明，较低的骨钙素与符合精神障碍标准有关，OR = 0.43，95%CI [.002，.924]，并与一系列升高的精神病理学症状呈中度至大量横断面关联，Bs ≥ |-3.44|，ps ≤.034。多层次线性增长模型表明，低骨钙素在一年的随访中前瞻性地预测了更广泛的精神病理学症状，以及一些症状随时间的增加，Bs ≥ |-1.83|，ps ≤.021。研究结果表明，骨钙素是青少年多种形式精神病理学的生物标志物。骨钙素是一种潜在的跨诊断机制，通过这种机制，对压力的失调反应可能导致或加重各种类型的精神病理学，突出了对临床评估和早期干预的有希望的目标。
