Kang Ning, Huang Jie, Han Xiaoguang, Li Zhengqian, Yuan Yi, Guo Xiangyang, Yang Ning
Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Front Pharmacol. 2025 Jul 14;16:1646558. doi: 10.3389/fphar.2025.1646558. eCollection 2025.
Osteocalcin (OCN), a bone-derived hormone, considered as an indicator of bone turnover. Beyond its canonical role in bone metabolism, OCN may have many other functions as well. Studies have shown that it may also regulate glucose and lipid metabolism, cognitive function, sexual function, and more. Recently, OCN has become one interesting hormone with potential effects on acute stress response (ASR), which is essential for vertebrates' survival. This review aims to comprehensively summarize the progress on the role of OCN in the pathophysiology of ASR and to thoroughly analyze the molecular mechanisms and significance of OCN in modulating ASR. In summary, a deeper understanding of OCN's role in the ASR will help reveal how bone-derived signals integrate into stress regulatory networks and may guide the development of novel strategies to prevent or treat stress-related disorders (e.g., anxiety, depression, or stress-aggravated cardiac events). By focusing on the emerging OCN-stress axis, our review highlights an expanding perspective on bone as an endocrine organ influencing stress physiology.
骨钙素（OCN）是一种骨源性激素，被视为骨转换的指标。除了在骨代谢中的经典作用外，OCN可能还具有许多其他功能。研究表明，它还可能调节糖脂代谢、认知功能、性功能等。最近，OCN已成为一种对急性应激反应（ASR）具有潜在影响的有趣激素，而急性应激反应对脊椎动物的生存至关重要。本综述旨在全面总结OCN在急性应激反应病理生理学中作用的研究进展，并深入分析OCN调节急性应激反应的分子机制及意义。总之，深入了解OCN在急性应激反应中的作用将有助于揭示骨源性信号如何整合到应激调节网络中，并可能指导预防或治疗应激相关疾病（如焦虑、抑郁或应激加重的心脏事件）的新策略的开发。通过关注新兴的OCN-应激轴，我们的综述突出了将骨视为影响应激生理学的内分泌器官的不断扩展的观点。
