Huclier-Markai S, Medvedev D G, Cutler C S
SUBATECH, UMR 6457, Nantes Université / IMT Atlantique / CNRS-IN2P3, 4 rue Alfred Kastler La Chantrerie, BP 20722, 44307 Nantes, France; ARRONAX, 1 Rue Aronnax - CS 10112, 44817 Saint-Herblain Cedex, France; Brookhaven National Laboratory, Isotope Research and Production Department, Upton, NY 11973, USA.
Brookhaven National Laboratory, Isotope Research and Production Department, Upton, NY 11973, USA.
Appl Radiat Isot. 2024 Oct;212:111451. doi: 10.1016/j.apradiso.2024.111451. Epub 2024 Jul 20.
Sc-radiopharmaceuticals are gaining more interest but still lack availability. The proof of principle of aTi/Sc generator, which can produce Sc daily, has been established but with some limitations and drawbacks. Despite recent advances, separation of Ti from massive quantities of scandium target material is still cumbersome. In this work, the improved radiochemical separation of Ti from residual scandium target material was carried out by precipitation of Sc with fluoride ions. Furthermore, two approaches were used to set up a high apparent molar activity small-scale generator. The first method relied on extraction chromatography for fine purification using a DGA resin, followed by loading of the purified Ti onto a ZR resin column. In the second method, Ti was loaded on the ZR resin directly after the precipitation step. This second method was used to set up a generator of 370 kBq and evaluate by radiolabeling. An apparent molar activity of 2 MBq/nmol was obtained for the radiolabeling with DOTA, the most common and suitable chelate for scandium. This result is comparable with previously published data on Sc.
钪放射性药物越来越受到关注，但仍然难以获得。每天能够生产钪的钛/钪发生器的原理已经得到验证，但存在一些局限性和缺点。尽管最近有进展，但从大量钪靶材料中分离钛仍然很麻烦。在这项工作中，通过用氟离子沉淀钪，实现了从残留钪靶材料中改进的放射化学分离。此外，采用两种方法建立了高比活度的小型发生器。第一种方法依靠使用二甘醇酰胺（DGA）树脂的萃取色谱法进行精细纯化，然后将纯化后的钛加载到锆树脂柱上。第二种方法是在沉淀步骤后直接将钛加载到锆树脂上。使用第二种方法建立了一个370 kBq的发生器，并通过放射性标记进行评估。用钪最常用且合适的螯合剂二乙基三胺五乙酸（DOTA）进行放射性标记时，获得了2 MBq/nmol的比活度。该结果与先前发表的关于钪的数据相当。
