Shandong Key Laboratory of Medical and Health Textile Materials, Laboratory for Manufacturing Low Carbon and Functionalized Textiles in the Universities of Shandong Province, College of Textiles & Clothing, Qingdao University, Qingdao 266071, China.
Qingdao Xinwei Textile Development Co., Ltd, Qingdao 266000, China.
Int J Biol Macromol. 2024 Oct;277(Pt 2):134237. doi: 10.1016/j.ijbiomac.2024.134237. Epub 2024 Jul 30.
A novel gingival retraction cord named P/TA@CSy was prepared using chitosan yarns (CSy) loaded with tranexamic acid (TA) and Propolis (P). P/TA@CSy has good toughness with a breaking strength of 41.3 Pa, benefiting from the twisting structure and Propolis coating. A short coagulation time of 456 s was achieved for P/TA@CSy because of the potent blood absorption ability from the effective attachment of tranexamic acid. Moreover, excellent antibacterial ability was obtained with the antibacterial rates against E. coli of 94.73 %, S. aureus of 99.99 % and S. mutans of 99.99 %, contributing to Propolis's antibacterial ability. In addition, suppression of the expression of pro-inflammatory cytokines (IL-6 and TNF-α) was found, which could prevent wound infection. P/TA@CSy displayed excellent cytocompatibility with the cell activity of 100 % after 24 h. Therefore, P/TA@CSy could rapidly respond to gingival hemostasis and infection prevention, showing excellent potential in dental treatment.
一种新型的牙龈退缩结扎线 P/TA@CSy 是由负载氨甲环酸（TA）和蜂胶（P）的壳聚糖线（CSy）制备而成。P/TA@CSy 具有良好的韧性，断裂强度为 41.3 Pa，这得益于其扭结构和蜂胶涂层。由于氨甲环酸的有效附着，具有很强的血液吸收能力，因此 P/TA@CSy 的凝结时间很短，仅为 456 s。此外，由于蜂胶具有抗菌能力，因此还获得了优异的抗菌能力，对大肠杆菌的抗菌率为 94.73%，对金黄色葡萄球菌的抗菌率为 99.99%，对变形链球菌的抗菌率为 99.99%。此外，还发现其抑制促炎细胞因子（IL-6 和 TNF-α）的表达，从而可以预防伤口感染。P/TA@CSy 在 24 小时后显示出出色的细胞相容性，细胞活性为 100%。因此，P/TA@CSy 可以快速响应牙龈止血和预防感染，在牙科治疗中具有出色的应用潜力。
