Department of Clinical Endocrinology IV, Carol Davila University of Medicine and Pharmacy Bucharest, Romania; CI Parhon National Institute of Endocrinology, 34-36 Aviatorilor Boulevard, Sector 1, 011863, Bucharest, Romania.
Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon, USA; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA; Pituitary Center, Oregon Health & Science University, Portland, OR, USA.
Endocrinol Metab Clin North Am. 2024 Sep;53(3):421-435. doi: 10.1016/j.ecl.2024.05.007.
Pregnancy is rare in women with Cushing's syndrome (CS), due to hypercortisolism-induced gonadotropin suppression and anovulation. Diagnosis of CS is hampered by physiological cortisol level increases during normal pregnancy; importantly abnormal cortisol secretion circadian rhythm could be diagnostic. Active CS is associated with considerable maternal and fetal complications. Second trimester surgery (pituitary or adrenal) is the main treatment option, however observation in mild cases has been suggested. Medical treatment, although not approved for use in pregnancy, may be considered, after careful discussion and balancing any benefits with potential risks and side-effects.
库欣综合征（CS）患者妊娠罕见，这是由于皮质醇增多导致促性腺激素抑制和排卵障碍。CS 的诊断受到正常妊娠期间皮质醇水平生理性升高的阻碍；重要的是，异常的皮质醇分泌昼夜节律可能具有诊断意义。活动性 CS 与母体和胎儿并发症密切相关。妊娠中期手术（垂体或肾上腺）是主要的治疗选择，但也有建议对轻度病例进行观察。尽管尚未批准在妊娠期间使用药物治疗，但在仔细讨论并权衡任何益处与潜在风险和副作用后，可能会考虑使用。
