Espinoza C G, Erkman-Balis B, Fenske N A
J Am Acad Dermatol. 1985 Nov;13(5 Pt 1):736-43. doi: 10.1016/s0190-9622(85)70215-0.
In an attempt to better define the process of lymphomatoid papulosis, two cases were studied by means of light and electron microscopy, immunohistochemistry studies, including the use of monoclonal antibodies, and cytogenetic technics. About 90% of the dermal lymphoid infiltrate, including the atypical cells, reacted with antibodies that define helper-inducer T cells. Only a few cells, about 5%, reacted with antibodies that define cytotoxic-suppressor T cells. Langerhans cells were increased mostly within the epidermis, and in the dermis they were in close proximity to lymphoid cells. Cytogenetic studies disclosed an abnormal hypertetraploid karyotype in dividing cells from the skin lesion, whereas skin fibroblast and phytohemagglutinin-stimulated cells from peripheral blood cultures had a diploid karyotype. The results support the concept that lymphomatoid papulosis is a disorder characterized by a predominance of helper-inducer T cells, including the atypical cells bearing an abnormal karyotype.
为了更好地界定淋巴瘤样丘疹病的发病过程，我们通过光学显微镜和电子显微镜、免疫组织化学研究（包括使用单克隆抗体）以及细胞遗传学技术对两例病例进行了研究。包括非典型细胞在内，约90%的真皮淋巴样浸润细胞与可界定辅助诱导性T细胞的抗体发生反应。仅有少数细胞（约5%）与可界定细胞毒性抑制性T细胞的抗体发生反应。朗格汉斯细胞主要在表皮内增多，在真皮中它们与淋巴样细胞紧密相邻。细胞遗传学研究显示，皮肤损害处分裂细胞存在异常的超四倍体核型，而皮肤成纤维细胞和外周血培养物中经植物血凝素刺激的细胞具有二倍体核型。这些结果支持了这样一种观点，即淋巴瘤样丘疹病是一种以辅助诱导性T细胞占优势为特征的疾病，包括具有异常核型的非典型细胞。
