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Knockout of M-LP/Mpv17L, a newly identified atypical PDE, alleviates diabetic conditions in mice.

作者信息

Iida Reiko, Ueki Misuzu, Yasuda Toshihiro

机构信息

Molecular Neuroscience Unit, School of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan.

Organization for Life Science Advancement Programs, University of Fukui, Fukui, 910-1193, Japan.

出版信息

Acta Diabetol. 2024 Oct;61(10):1327-1331. doi: 10.1007/s00592-024-02337-7. Epub 2024 Jul 31.

DOI:10.1007/s00592-024-02337-7
PMID:39085522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11486820/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8073/11486820/7031d3ef4dca/592_2024_2337_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8073/11486820/b515b97eb059/592_2024_2337_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8073/11486820/7031d3ef4dca/592_2024_2337_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8073/11486820/b515b97eb059/592_2024_2337_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8073/11486820/7031d3ef4dca/592_2024_2337_Fig2_HTML.jpg

相似文献

1
Knockout of M-LP/Mpv17L, a newly identified atypical PDE, alleviates diabetic conditions in mice.敲除新发现的非典型磷酸二酯酶M-LP/Mpv17L可缓解小鼠的糖尿病症状。
Acta Diabetol. 2024 Oct;61(10):1327-1331. doi: 10.1007/s00592-024-02337-7. Epub 2024 Jul 31.
2
Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.敲除新鉴定的非典型 PDE M-LP/Mpv17L 可诱导小鼠生理性传入性心肌肥厚。
Transgenic Res. 2023 Dec;32(6):575-582. doi: 10.1007/s11248-023-00373-7. Epub 2023 Oct 18.
3
Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways.M-LP/Mpv17L 的缺乏导致 β 细胞增生和葡萄糖耐量改善，这是通过 Wnt 和 TGF-β 通路的激活实现的。
Biochim Biophys Acta Mol Basis Dis. 2022 Mar 1;1868(3):166318. doi: 10.1016/j.bbadis.2021.166318. Epub 2021 Dec 6.
4
Human Mpv17-like protein with a mitigating effect on mtDNA damage is involved in cAMP/PKA signaling in the mitochondrial matrix.人类具有减轻线粒体 DNA 损伤作用的 Mpv17 样蛋白，参与线粒体基质中的 cAMP/PKA 信号转导。
Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118792. doi: 10.1016/j.bbamcr.2020.118792. Epub 2020 Jul 2.
5
Prediction of novel isoforms of the mouse Mpv17l protein.预测小鼠 Mpv17l 蛋白的新型异构体。
Genome. 2009 Nov;52(11):968-74. doi: 10.1139/g09-061.
6
Cyclic nucleotide phosphodiesterase and aggregation in platelets from diabetic rats.糖尿病大鼠血小板中的环核苷酸磷酸二酯酶与聚集
Metabolism. 1982 Jul;31(7):704-9. doi: 10.1016/0026-0495(82)90201-3.
7
Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes.选择性磷酸二酯酶-5（PDE-5）抑制剂伐地那非通过恢复足细胞中环鸟苷酸（cGMP）水平改善 1 型糖尿病大鼠的肾损伤。
Nephrol Dial Transplant. 2013 Jul;28(7):1751-61. doi: 10.1093/ndt/gfs391. Epub 2012 Nov 29.
8
Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice.环核苷酸磷酸二酯酶：C3H小鼠遗传性视网膜变性的早期缺陷
J Cell Biol. 1973 Apr;57(1):117-23. doi: 10.1083/jcb.57.1.117.
9
Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents.心脏、平滑肌和血小板中环核苷酸磷酸二酯酶的多种分子形式。各种参考磷酸二酯酶抑制剂和强心剂的分离、特性及作用。
Biochem Pharmacol. 1986 Mar 1;35(5):787-800. doi: 10.1016/0006-2952(86)90247-9.
10
Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases.磷酸二酯酶抑制剂、咪唑和磷酸盐对环CMP磷酸二酯酶的作用不同于它们对环AMP和环GMP磷酸二酯酶的作用。
J Cyclic Nucleotide Res. 1978 Dec;4(6):463-74.

本文引用的文献

1
Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease.鉴定实验性糖尿病肾病发病机制中的新型关键分子特征。
Front Endocrinol (Lausanne). 2022 Mar 30;13:843721. doi: 10.3389/fendo.2022.843721. eCollection 2022.
2
Deficiency of M-LP/Mpv17L leads to development of β-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-β pathways.M-LP/Mpv17L 的缺乏导致 β 细胞增生和葡萄糖耐量改善，这是通过 Wnt 和 TGF-β 通路的激活实现的。
Biochim Biophys Acta Mol Basis Dis. 2022 Mar 1;1868(3):166318. doi: 10.1016/j.bbadis.2021.166318. Epub 2021 Dec 6.
3
Human Mpv17-like protein with a mitigating effect on mtDNA damage is involved in cAMP/PKA signaling in the mitochondrial matrix.
人类具有减轻线粒体 DNA 损伤作用的 Mpv17 样蛋白，参与线粒体基质中的 cAMP/PKA 信号转导。
Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118792. doi: 10.1016/j.bbamcr.2020.118792. Epub 2020 Jul 2.
4
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets.
Biochem Pharmacol. 2008 Oct 1;76(7):884-93. doi: 10.1016/j.bcp.2008.07.025. Epub 2008 Jul 26.
5
Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family.小鼠M-LP的克隆、定位、基因组结构及表达，M-LP是过氧化物酶体膜蛋白Mpv17结构域家族的一个新成员。
Biochem Biophys Res Commun. 2001 May 4;283(2):292-6. doi: 10.1006/bbrc.2001.4769.