通过双光氧化还原/镍催化的C-O偶联合成六氟异丙基芳基醚
Synthesis of Hexafluoroisopropyl Aryl Ethers via Dual Photoredox/Nickel-Catalyzed C-O Coupling.
作者信息
He Xu, Zhang Yu-Yang, Shou Jia-Yi, Chu Lingling, Qing Feng-Ling
机构信息
Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Science, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 201620, China.
出版信息
Org Lett. 2024 Aug 9;26(31):6782-6786. doi: 10.1021/acs.orglett.4c02553. Epub 2024 Jul 31.
Herein we report a photoredox/nickel-catalyzed cross-coupling of aryl bromides with 1,1,1,3,3,3-hexafluoroisopropanol for the construction of hexafluoroisopropyl aryl ethers. The mild reaction conditions employed allow for the applicability of a wide range of aryl and heteroaryl bromides. Late-stage functionalization and preliminary mechanistic studies have been demonstrated.
在此，我们报道了一种光氧化还原/镍催化的芳基溴化物与1,1,1,3,3,3-六氟异丙醇的交叉偶联反应，用于构建六氟异丙基芳基醚。所采用的温和反应条件使得多种芳基和杂芳基溴化物都适用。已证明了后期官能团化和初步机理研究。
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