Van Ussel Kevin, Leonard Daniel, Watremez Christine, Robu Cristina Bianca
Department of Anesthesiology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Av Hippocrate 10, Brussels, 1200, Belgium.
, Brussels, Belgium.
BMC Anesthesiol. 2024 Jul 31;24(1):265. doi: 10.1186/s12871-024-02648-w.
Carcinoid tumors are rare neuroendocrine malignancies presenting in an increasing number in our center. The incidence of carcinoid tumors is approximatively between 2.5 and 5 cases per 100,000 people of whom about 50% develop carcinoid syndrome. Once the carcinoid syndrome has developed, a carcinoid cardiomyopathy can occur. Carcinoid heart disease (CaHD) remains a serious and rare complication associated with a significant increase in morbidity and mortality. Although carcinoid tumors have been known and studied for several years, there are still scarce data on the anesthetic management and the peri operative period.
We describe a case of a Caucasian 44-year-old woman with an unusual presentation of left CaHD with an ileal neuroendocrine tumor and liver metastases. Our preoperative somatostatin administration protocol, limit the cardiac damage. The maintenance of stable hemodynamics, the use of balanced anesthetic technique, all along with a good understanding of the pathology, played a major role in the successful management of anesthesia. This case report allows us to introduce our decision algorithm for the management of this type of pathology in our tertiary hospital, Cliniques Universitaires Saint-Luc.
Despite the paucity of data, anesthetic management of patients with carcinoid tumor can be safely performed with effective hemodynamic monitoring and a good understanding of the pathophysiology. Knowledge and application of a clear institutional algorithm for octreotide administration and multidisciplinary consultation at a referral center are essential for the management of these patients.
类癌肿瘤是罕见的神经内分泌恶性肿瘤,在我们中心的发病率呈上升趋势。类癌肿瘤的发病率约为每10万人中有2.5至5例,其中约50%会发展为类癌综合征。一旦发生类癌综合征,就可能出现类癌性心肌病。类癌性心脏病(CaHD)仍然是一种严重且罕见的并发症,会导致发病率和死亡率显著增加。尽管类癌肿瘤已被认识和研究多年,但关于麻醉管理和围手术期的数据仍然很少。
我们描述了一例44岁的白种女性,患有不寻常的左CaHD,伴有回肠神经内分泌肿瘤和肝转移。我们术前使用生长抑素的方案限制了心脏损伤。维持稳定的血流动力学、采用平衡麻醉技术以及对病理的充分了解,在麻醉的成功管理中发挥了重要作用。本病例报告使我们能够介绍我们在圣吕克大学医院对这类病理情况的管理决策算法。
尽管数据有限,但通过有效的血流动力学监测和对病理生理学的充分了解,可以安全地对类癌肿瘤患者进行麻醉管理。在转诊中心,了解并应用明确的奥曲肽给药机构算法以及多学科会诊对于这些患者的管理至关重要。