核糖体DNA甲基化在胚胎发育、衰老及疾病中的作用。
The role of ribosomal DNA methylation in embryonic development, aging and diseases.
作者信息
Yang Fei, Guo Xutong, Bao Yiming, Li Rujiao
机构信息
National Genomics Data Center, China National Center for Bioinformation, Beijing, 100101, China.
Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
出版信息
Epigenetics Chromatin. 2024 Jul 31;17(1):23. doi: 10.1186/s13072-024-00548-4.
The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleolus, and responsible for coding three major types of rRNAs (18S, 5.8S and 28S). While historical investigations into rDNA focused on its structure and coding capabilities, recent research has turned to explore its functional roles in various biological processes. In this review, we summarize the main findings of rDNA methylation with embryonic development, aging and diseases in multiple species, including epigenetic alterations, related biological processes and potential applications of rDNA methylation. We present an overview of current related research and identify gaps in this field.
核糖体DNA（rDNA）在物种内构成一种高度保守的DNA序列，位于核仁区域，负责编码三种主要类型的核糖体RNA（18S、5.8S和28S）。虽然对rDNA的历史研究集中在其结构和编码能力上，但最近的研究已转向探索其在各种生物学过程中的功能作用。在本综述中，我们总结了rDNA甲基化在多个物种的胚胎发育、衰老和疾病方面的主要研究结果，包括表观遗传改变、相关生物学过程以及rDNA甲基化的潜在应用。我们概述了当前的相关研究，并指出了该领域的空白。
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