From the PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University.
Clin Nucl Med. 2024 Sep 1;49(9):817-821. doi: 10.1097/RLU.0000000000005374. Epub 2024 Jul 31.
To investigate the role of CXCR4-targeted 68 Ga-pentixafor PET/CT imaging in inflammatory bowel disease (IBD).
Five IBD patients and 12 control subjects performing 68 Ga-pentixafor PET/CT examinations were included. 68 Ga-pentixafor PET/CT imaging and endoscopic findings were recorded and compared. The semiquantitative parameters of 68 Ga-pentixafor uptake by the lesion segments in IBD patients and the normal intestines in the control were investigated.
Among these 5 IBD patients, endoscopy successfully examined a total of 26 intestinal segments, with 13 segments showing endoscopic lesions. 68 Ga-pentixafor PET/CT was positive in all endoscopy-proven lesions (13/13). Additionally, 68 Ga-pentixafor PET/CT revealed the lesions in small intestines and colons that cannot be reached by endoscopy due to severe stenosis, and mesenteric lymphadenitis accompanied IBD. The SUV max of the lesion segments in IBD patients was significantly higher than that of the normal intestines in the control group (median, 3.15 [range, 1.61-6.26] vs 1.67 [1.18-2.29], P < 0.001). Moreover, the SUV max ratios of the lesion segments/liver or blood pool were higher when compared with the control (2.20 [1.13-3.26] vs 0.85 [0.54-1.20]; 1.66 [0.94-2.95] vs 0.67 [0.52-1.04]; P ≤ 0.001).
68 Ga-pentixafor PET/CT can be a potentially valuable tool to assess the active intestinal lesions of IBD with high sensitivity. Moreover, this noninvasive approach does not require fasting or bowel preparation, offering good tolerance and safety.
研究 CXCR4 靶向的 68Ga-戊替克斯佛 PET/CT 成像在炎症性肠病（IBD）中的作用。
纳入 5 例 IBD 患者和 12 例进行 68Ga-戊替克斯佛 PET/CT 检查的对照者。记录并比较 68Ga-戊替克斯佛 PET/CT 成像和内镜检查结果。研究 IBD 患者病变节段和对照者正常肠段对 68Ga-戊替克斯佛摄取的半定量参数。
在这 5 例 IBD 患者中，内镜成功检查了总共 26 个肠段，其中 13 个肠段有内镜下病变。68Ga-戊替克斯佛 PET/CT 对所有经内镜证实的病变（13/13）均呈阳性。此外，68Ga-戊替克斯佛 PET/CT 显示了由于严重狭窄而无法通过内镜到达的小肠和结肠病变以及伴有 IBD 的肠系膜淋巴结炎。IBD 患者病变节段的 SUVmax 明显高于对照者的正常肠段（中位数，3.15[范围，1.61-6.26] vs 1.67[1.18-2.29]，P<0.001）。此外，与对照者相比，病变节段/肝脏或血池的 SUVmax 比值更高（2.20[1.13-3.26] vs 0.85[0.54-1.20]；1.66[0.94-2.95] vs 0.67[0.52-1.04]；P≤0.001）。
68Ga-戊替克斯佛 PET/CT 可能是一种评估 IBD 活动性肠内病变的高灵敏度、有潜在价值的工具。此外，这种非侵入性方法不需要禁食或肠道准备，具有良好的耐受性和安全性。
