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Exendin-4 imaging based on gastrointestinal GLP-1R targets for IBD diagnosis and efficacy assessment.基于胃肠道胰高血糖素样肽-1受体(GLP-1R)靶点的艾塞那肽-4成像在炎症性肠病诊断及疗效评估中的应用
Eur J Nucl Med Mol Imaging. 2025 Apr 3. doi: 10.1007/s00259-025-07197-z.
2
CD45-PET is a robust, non-invasive tool for imaging inflammation.CD45正电子发射断层扫描是一种用于炎症成像的强大的非侵入性工具。
Nature. 2025 Mar;639(8053):214-224. doi: 10.1038/s41586-024-08441-6. Epub 2025 Jan 22.
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Trends in nanobody radiotheranostics.纳米抗体放射诊疗学的发展趋势。
Eur J Nucl Med Mol Imaging. 2025 May;52(6):2225-2238. doi: 10.1007/s00259-025-07077-6. Epub 2025 Jan 13.
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Role of Total Body PET/CT in Inflammatory Disorders.全身PET/CT在炎症性疾病中的作用
Semin Nucl Med. 2025 Jan;55(1):41-51. doi: 10.1053/j.semnuclmed.2024.11.001. Epub 2024 Nov 21.
5
Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis.可视化免疫检查点抑制剂在动脉粥样硬化中的炎症反应。
Circ Res. 2024 Oct 25;135(10):990-1003. doi: 10.1161/CIRCRESAHA.124.324260. Epub 2024 Sep 27.
6
F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis.F-FDG-PET/MR 成像用于监测大血管血管炎的疾病活动。
Nat Commun. 2024 Aug 25;15(1):7314. doi: 10.1038/s41467-024-51613-1.
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CXCR4-Targeted 68 Ga-Pentixafor PET/CT Imaging in Inflammatory Bowel Disease.靶向 CXCR4 的 68Ga- Pentixafor PET/CT 成像在炎症性肠病中的应用。
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Granzyme B PET Imaging for Assessment of Disease Activity in Inflammatory Bowel Disease.颗粒酶 B PET 显像用于评估炎症性肠病的疾病活动度。
J Nucl Med. 2024 Jul 1;65(7):1137-1143. doi: 10.2967/jnumed.123.267344.
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PSMA-Targeted PET Radiotracer [F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease.PSMA靶向PET放射性示踪剂[F]DCFPyL作为炎症性肠病的成像生物标志物
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10
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靶向CD45的正电子发射断层扫描(PET)能够实现炎症状态的可视化。

CD45-targeted PET enables the visualization of inflammatory conditions.

作者信息

Li Chongjiao, Song Zhendong, Hu Qilong, Li Yinlong, Patel Jimmy S, Liang Steven H

机构信息

Department of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, USA.

出版信息

Am J Nucl Med Mol Imaging. 2025 Jun 25;15(3):124-129. doi: 10.62347/VFWR2835. eCollection 2025.

DOI:10.62347/VFWR2835
PMID:40688532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12267089/
Abstract

Inflammation is a major contributor to human mortality, accounting for over 50% of deaths worldwide. Therefore, there is an urgent need for early and accurate diagnostic methods. PET imaging targeting leukocyte common antigen CD45 presents a promising approach for detecting inflammation and monitoring therapeutic responses.

摘要

炎症是导致人类死亡的主要因素,全球超过50%的死亡病例与之相关。因此,迫切需要早期准确的诊断方法。靶向白细胞共同抗原CD45的正电子发射断层扫描(PET)成像为检测炎症和监测治疗反应提供了一种很有前景的方法。