Division of Infection and Immunity and Institute of Immunity and Transplantation, Royal Free Hospital, University College London, London, United Kingdom.
Eur J Immunol. 2024 Nov;54(11):e2350496. doi: 10.1002/eji.202350496. Epub 2024 Jul 31.
Regulatory B cells (Bregs) are a functionally distinct B-cell subset involved in the maintenance of homeostasis and inhibition of inflammation. Studies, from the last two decades, have increased our understanding of cellular and molecular mechanisms involved in their generation, function, and to a certain extent phenotype. Current research endeavours to unravel the causes and consequences of Breg defects in disease, with increasing evidence highlighting the relevance of Bregs in promoting tumorigenic responses. Here we provide historical and emerging findings of the significance of Bregs in autoimmunity and transplantation, and how these insights have translated into the cancer field.
调节性 B 细胞（Bregs）是一类具有独特功能的 B 细胞亚群，参与维持内环境稳定和抑制炎症反应。过去二十年的研究加深了我们对其产生、功能以及在一定程度上表型的细胞和分子机制的理解。目前的研究努力旨在揭示 Breg 缺陷在疾病中的原因和后果，越来越多的证据强调了 Bregs 在促进肿瘤发生反应中的相关性。在这里，我们提供了 Bregs 在自身免疫和移植中的意义的历史和新发现，以及这些见解如何转化到癌症领域。
