Infectious Disease Unit and Division of Applied Medical Sciences, King Fahad Centre for medical research, King Abdulaziz University, Jeddah, Saudi Arabia.
Peter Gorer Department of Immunobiology, MRC Centre for Transplantation, School of Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, UK.
Immunol Rev. 2019 Nov;292(1):164-179. doi: 10.1111/imr.12800. Epub 2019 Sep 27.
The interest in regulatory B cells (Bregs) began in the 1970s with the evidence that B cells could downregulate the immune system by the production of "inhibitory" antibodies. Subsequently, a series of results from different studies have emphasized that B cells have antibody-independent immunoregulatory functions. Since then, different subsets of B cells with regulatory functions and their development and mechanisms of action have been identified both in human and in animal models of inflammation, transplantation, and autoimmunity. The present review outlines the suggested pathways by which Bregs develop, describes the different subsets of Bregs with their phenotypes and function as well as their role in transplantation, highlighting the differences between human and animal studies throughout.
人们对调节性 B 细胞（Bregs）的兴趣始于 20 世纪 70 年代，当时有证据表明 B 细胞可以通过产生“抑制性”抗体来下调免疫系统。随后，来自不同研究的一系列结果强调了 B 细胞具有抗体非依赖性的免疫调节功能。从那时起，在人类和炎症、移植和自身免疫的动物模型中，已经确定了具有调节功能的不同 B 细胞亚群及其发育和作用机制。本文综述了 Bregs 发育的可能途径，描述了不同的 Bregs 亚群及其表型和功能，以及它们在移植中的作用，强调了贯穿始终的人类和动物研究之间的差异。
