Orisakwe Orish E, Ikpeama Evelyn Utomoibor, Orish Chinna N, Ezejiofor Anthonet N, Ozoani Harrison Anezi, Okolo Kenneth O, Cirovic Aleksandar, Cirovic Ana, Nwaogazie Ify L
African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Port Harcourt, Choba, Nigeria.
Advanced Research Centre, European University of Lefke, Lefke, Northern Cyprus, Turkey.
Nat Prod Res. 2024 Jul 31:1-5. doi: 10.1080/14786419.2024.2381018.
African mesquite AM is widely used as an anti-inflammatory agent in sub-Sahara Africa especially Nigeria. Given its strong anti-inflammatory potency, this study has evaluated the neuroprotective properties of AM in the hippocampus HIP and olfactory bulb OB of rats exposed to Cd, As, Hg, and Pb. Twenty-five albino Sprague Dawley rats were randomly divided into five groups in this experiment. Group 1, the control received only water. Group 2 received heavy metal mixture HMM (PbCl (20 mg/kg), CdCl (1.61 mg/kg), HgCl (0.40 mg/kg), and NaAsO (10 mg/kg), for 60 days. Groups 3, 4, and 5 were treated with HMM along with AM at doses of 500, 1000, and 1500 mg/kg, respectively. AM decreased the Cd, As, Hg, and Pb levels in OB and HIP, restored the activities of antioxidants, Hmox-1, reduced the activities of AChE, NRF2 and NFkB and improved histopathology.
非洲牧豆树（African mesquite，AM）在撒哈拉以南非洲地区尤其是尼日利亚被广泛用作抗炎剂。鉴于其强大的抗炎效力，本研究评估了AM对暴露于镉（Cd）、砷（As）、汞（Hg）和铅（Pb）的大鼠海马体（HIP）和嗅球（OB）的神经保护特性。在本实验中，将25只白化斯普拉格-道利大鼠随机分为五组。第1组为对照组，仅给予水。第2组接受重金属混合物（HMM，含氯化铅（20 mg/kg）、氯化镉（1.61 mg/kg）、氯化汞（0.40 mg/kg）和砷酸钠（10 mg/kg）），持续60天。第3、4和5组分别用500、1000和1500 mg/kg剂量的AM与HMM联合处理。AM降低了OB和HIP中的Cd、As、Hg和Pb水平，恢复了抗氧化剂、血红素加氧酶-1（Hmox-1）的活性，降低了乙酰胆碱酯酶（AChE）、核因子E2相关因子2（NRF2）和核因子κB（NFkB）的活性，并改善了组织病理学。
