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锌和硒可消除重金属混合物在雌性白化大鼠中通过激活NRF2-HMOX-1介导的卵巢和甲状腺氧化炎症效应。

Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats.

作者信息

Eddie-Amadi Boma F, Ezejiofor Anthonet N, Orish Chinna N, Orisakwe Orish E

机构信息

World Bank Africa Centre of Excellence in Oilfield Chemicals Research (ACE-CEFOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Choba, Nigeria.

African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Choba, Nigeria.

出版信息

Curr Res Toxicol. 2022 Dec 22;4:100098. doi: 10.1016/j.crtox.2022.100098. eCollection 2023.

DOI:10.1016/j.crtox.2022.100098
PMID:36624872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9823124/
Abstract

The thyroid is vital for the proper functioning of the female reproductive system since it regulates the metabolism and development of ovary. This is an evaluation of the essential trace elements ETE on the heavy metals mixture HMM mediated oxido-inflammatory effects in the ovary and thyroid of female albino rats. Eight groups (5 female rats /group) were treated as follows for 60 days: Group 1: Deionized water only; Group 2: (Pb, Hg, Mn and Al); Group 3: HMM + ZnCl, 0.80 mg/kg; Group 4: HMM + NaSeO, 1.50 mg/kg; Group 5: HMM + ZnCl, 0.80 mg/kg and NaSeO, 1.50 mg/kg combined. On day 60 animals were euthanized, ovary and thyroid were harvested and used for, MDA, NO, antioxidants, TNF-α, IL-6, HMOX-1, Caspase-3, NF-KB, NRF2, HM and histopathology. There was significant bioaccumulation of Pb, Al, Hg and MN; elevated IL-6 and TNF-α, MDA and NO, caspase-3 and NRF2, NFKB and HMOX-1 with significant decrease in antioxidants in the HMM only group in comparison to the control. Co-treatment with ETE reversed most of these effects. ETE may ameliorate HMM -induced ovarian and thyrotoxicity in female albino rats by blunting oxido-inflammatory activities.

摘要

甲状腺对于女性生殖系统的正常功能至关重要，因为它调节卵巢的新陈代谢和发育。这是一项关于必需微量元素（ETE）对重金属混合物（HMM）介导的雌性白化大鼠卵巢和甲状腺氧化炎症效应的评估。八组（每组5只雌性大鼠）接受如下处理，为期60天：第1组：仅给予去离子水；第2组：（铅、汞、锰和铝）；第3组：HMM + 氯化锌，0.80毫克/千克；第4组：HMM + 亚硒酸钠，1.50毫克/千克；第5组：HMM + 氯化锌，0.80毫克/千克与亚硒酸钠，1.50毫克/千克联合使用。在第60天，对动物实施安乐死，采集卵巢和甲状腺用于检测丙二醛（MDA）、一氧化氮（NO）、抗氧化剂、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血红素加氧酶-1（HMOX-1）、半胱天冬酶-3（Caspase-3）、核因子-κB（NF-κB）、核因子E2相关因子2（NRF2）、重金属（HM）以及进行组织病理学检查。与对照组相比，仅HMM组中铅、铝、汞和锰有显著生物蓄积；白细胞介素-6、肿瘤坏死因子-α、丙二醛和一氧化氮、半胱天冬酶-3和核因子E2相关因子2、核因子-κB和血红素加氧酶-1升高，而抗氧化剂显著减少。与必需微量元素联合处理可逆转这些影响中的大多数。必需微量元素可能通过减弱氧化炎症活性来改善HMM诱导的雌性白化大鼠卵巢和甲状腺毒性。

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