Zhao Xin, Pei Ziqi, Song Xiang, Jin Gang
Department of Oncology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Head Neck. 2025 Jan;47(1):150-158. doi: 10.1002/hed.27862. Epub 2024 Jul 31.
Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.
Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.
The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.
Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.
鼻窦未分化癌（SNUC）是一种罕见的侵袭性疾病，治疗方式不明确，预后较差。本研究旨在评估放射治疗（RT）的作用并探索最佳治疗顺序。
回顾性分析1973年至2015年间410例SNUC患者的生存趋势。
在84个月的中位随访期内，报告了5年癌症特异性生存率（CSS）（45.1%）和总生存率（OS）（38.1%）。放射治疗是改善CSS（风险比[HR]=0.425，95%置信区间[CI]：0.299-0.603，p=0.000）和OS（HR=0.415，95%CI：0.303-0.570，p=0.000）的预后因素，无论是否联合手术（p=0.000）。然而，在手术和RT的联合治疗中，术前和术后放疗（5年OS率分别为47.1%和45.6%，p=0.486）无显著差异。
放射治疗在提高SNUC生存率方面起关键作用。术前和术后放疗的生存率无显著差异。
